This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Core-binding factor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 20: Line 20:
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Core-binding factor α
+
*Core-binding factor α subunit
**[[1ean]], [[1ljm]] – hCBFα runt domain - human<br />
**[[1ean]], [[1ljm]] – hCBFα runt domain - human<br />
-
**[[1cmo]] – hCBFα runt domain (mutant) - NMR<br />
+
**[[1cmo]], [[2n7b]] – hCBFα runt domain (mutant) - NMR<br />
**[[1co1]] – hCBFα runt domain - NMR<br />
**[[1co1]] – hCBFα runt domain - NMR<br />
**[[1eao]], [[1eaq]], [[2j6w]] – mCBFα runt domain (mutant) - mouse<br />
**[[1eao]], [[1eaq]], [[2j6w]] – mCBFα runt domain (mutant) - mouse<br />
**[[1hjc]] – mCBFα runt domain + DNA <br />
**[[1hjc]] – mCBFα runt domain + DNA <br />
**[[1hjb]] – mCBFα runt domain + hEBP β + DNA<br />
**[[1hjb]] – mCBFα runt domain + hEBP β + DNA<br />
-
**[[4l0y]], [[4l0z]], [[4l18]], [[4wu1]] – mCBFα runt domain + hETS1 + DNA<br />
+
**[[4l0y]], [[4l0z]], [[4l18]], [[3wu1]] – mCBFα runt domain + hETS1 + DNA<br />
-
*Core-binding factor α+β
+
*Core-binding factor β subunit
 +
 +
**[[1ilf]] – mCBFb<br />
 +
**[[4n9f]] – hCBFb + cullin-5 + transcription elongation factor B + virion infectivity factor<br />
 +
 
 +
*Core-binding factor α+β subunits
**[[1e50]] – hCBFα runt domain + hCBFβ heterodimerization domain<br />
**[[1e50]] – hCBFα runt domain + hCBFβ heterodimerization domain<br />

Revision as of 10:12, 4 April 2017

Human CBFα runt domain (magenta) complex with CBFβ heterodimerization domain (green) and DNA (PDB code 1h9d)

Drag the structure with the mouse to rotate

3D Structures of core-binding factor

Updated on 04-April-2017


References

  1. ↑ Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260 doi:http://dx.doi.org/10.1038/86264

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Core-binding_factor"
Personal tools