1u4h
From Proteopedia
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|PDB= 1u4h |SIZE=350|CAPTION= <scene name='initialview01'>1u4h</scene>, resolution 2.07Å | |PDB= 1u4h |SIZE=350|CAPTION= <scene name='initialview01'>1u4h</scene>, resolution 2.07Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Tar4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 Thermoanaerobacter tengcongensis]) | |GENE= Tar4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 Thermoanaerobacter tengcongensis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1u55|1U55]], [[1u56|1U56]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4h OCA], [http://www.ebi.ac.uk/pdbsum/1u4h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u4h RCSB]</span> | ||
}} | }} | ||
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[[Category: Marletta, M A.]] | [[Category: Marletta, M A.]] | ||
[[Category: Pellicena, P.]] | [[Category: Pellicena, P.]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: HEM]] | ||
| - | [[Category: OXY]] | ||
| - | [[Category: SCN]] | ||
[[Category: chemotaxis]] | [[Category: chemotaxis]] | ||
[[Category: h-nox domain]] | [[Category: h-nox domain]] | ||
| Line 37: | Line 36: | ||
[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:05:19 2008'' |
Revision as of 21:05, 30 March 2008
| |||||||
| , resolution 2.07Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | Tar4 (Thermoanaerobacter tengcongensis) | ||||||
| Related: | 1U55, 1U56
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)
Overview
Soluble guanylate cyclases are nitric oxide-responsive signaling proteins in which the nitric oxide sensor is a heme-binding domain of unknown structure that we have termed the heme-NO and oxygen binding (H-NOX) domain. H-NOX domains are also found in bacteria, either as isolated domains, or are fused through a membrane-spanning region to methyl-accepting chemotaxis proteins. We have determined the crystal structure of an oxygen-binding H-NOX domain of one such signaling protein from the obligate anaerobe Thermoanaerobacter tengcongensis at 1.77-angstroms resolution, revealing a protein fold unrelated to known structures. Particularly striking is the structure of the protoporphyrin IX group, which is distorted from planarity to an extent not seen before in protein-bound heme groups. Comparison of the structure of the H-NOX domain in two different crystal forms suggests a mechanism whereby alteration in the degree of distortion of the heme group is coupled to changes on the molecular surface of the H-NOX domain and potentially to changes in intermolecular interactions.
About this Structure
1U4H is a Single protein structure of sequence from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.
Reference
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases., Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J, Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9. Epub 2004 Aug 23. PMID:15326296
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