5j0b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the immune receptor CD33 in complex with 6'-sialyllactose== | |
| - | + | <StructureSection load='5j0b' size='340' side='right' caption='[[5j0b]], [[Resolution|resolution]] 2.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j0b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J0B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j0b OCA], [http://pdbe.org/5j0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j0b RCSB], [http://www.ebi.ac.uk/pdbsum/5j0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j0b ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN]] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dodd, R B]] | ||
| + | [[Category: Ig-like]] | ||
| + | [[Category: Immune receptor]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Sialic-acid binding]] | ||
| + | [[Category: Siglec]] | ||
Revision as of 13:25, 5 April 2017
Structure of the immune receptor CD33 in complex with 6'-sialyllactose
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