5j12

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'''Unreleased structure'''
 
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The entry 5j12 is ON HOLD until Paper Publication
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==Cytokine receptor complex==
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<StructureSection load='5j12' size='340' side='right' caption='[[5j12]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [http://pdbe.org/5j12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [http://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN]] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref> [[http://www.uniprot.org/uniprot/CRLF2_HUMAN CRLF2_HUMAN]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.<ref>PMID:11418668</ref> [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Savvides, S N]]
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[[Category: Verstraete, K]]
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[[Category: Cytokine inflammation tslp signaling complex]]
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[[Category: Signaling protein]]

Revision as of 13:26, 5 April 2017

Cytokine receptor complex

5j12, resolution 3.55Å

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