5j1x
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of neuropilin-1 b1 domain complexed with Arg-5 ligand.== | |
| - | + | <StructureSection load='5j1x' size='340' side='right' caption='[[5j1x]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j1x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J1X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR5:N~2~-(TERT-BUTOXYCARBONYL)-L-ARGININE'>AR5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1x OCA], [http://pdbe.org/5j1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j1x RCSB], [http://www.ebi.ac.uk/pdbsum/5j1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1x ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NRP1_HUMAN NRP1_HUMAN]] The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Djordjevic, S]] | ||
| + | [[Category: Fotinou, C]] | ||
[[Category: Rana, R]] | [[Category: Rana, R]] | ||
| - | [[Category: Fotinou, C]] | ||
| - | [[Category: Djordjevic, S]] | ||
[[Category: Yelland, T]] | [[Category: Yelland, T]] | ||
| + | [[Category: Angiogenesis]] | ||
| + | [[Category: Neuropilin-1]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 13:26, 5 April 2017
X-ray structure of neuropilin-1 b1 domain complexed with Arg-5 ligand.
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