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5jzb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HsaD bound to 3,5-dichlorobenzene sulphonamide== | |
| - | + | <StructureSection load='5jzb' size='340' side='right' caption='[[5jzb]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jzb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OT:3,5-DICHLOROBENZENE-1-SULFONAMIDE'>6OT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vf2|2vf2]], [[5jz9|5jz9]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzb OCA], [http://pdbe.org/5jzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzb RCSB], [http://www.ebi.ac.uk/pdbsum/5jzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU]] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Abihammad, A]] | ||
| + | [[Category: Ballet, R]] | ||
| + | [[Category: Bhakta, S]] | ||
| + | [[Category: Ciulli, A]] | ||
| + | [[Category: Eleftheriadou, O]] | ||
[[Category: Evangelopoulos, D]] | [[Category: Evangelopoulos, D]] | ||
| - | [[Category: Lack, N.A]] | ||
| - | [[Category: Ryan, A]] | ||
| - | [[Category: Ciulli, A]] | ||
[[Category: Halman, A]] | [[Category: Halman, A]] | ||
| + | [[Category: Keany, S]] | ||
| + | [[Category: Lack, N A]] | ||
| + | [[Category: Lowe, E]] | ||
| + | [[Category: McHugh, T D]] | ||
[[Category: Polycarpou, E]] | [[Category: Polycarpou, E]] | ||
| - | [[Category: | + | [[Category: Ryan, A]] |
[[Category: Sieg, C]] | [[Category: Sieg, C]] | ||
| - | [[Category: Ballet, R]] | ||
| - | [[Category: Keany, S]] | ||
| - | [[Category: Lowe, E]] | ||
| - | [[Category: Abihammad, A]] | ||
| - | [[Category: Eleftheriadou, O]] | ||
[[Category: Sim, E]] | [[Category: Sim, E]] | ||
[[Category: Sinclair, A]] | [[Category: Sinclair, A]] | ||
| - | [[Category: | + | [[Category: Cholesterol]] |
| + | [[Category: Hsad]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: M. tuberculosis]] | ||
| + | [[Category: Mcp-hydrolase]] | ||
Revision as of 13:26, 5 April 2017
Crystal structure of HsaD bound to 3,5-dichlorobenzene sulphonamide
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Categories: Abihammad, A | Ballet, R | Bhakta, S | Ciulli, A | Eleftheriadou, O | Evangelopoulos, D | Halman, A | Keany, S | Lack, N A | Lowe, E | McHugh, T D | Polycarpou, E | Ryan, A | Sieg, C | Sim, E | Sinclair, A | Cholesterol | Hsad | Hydrolase | Inhibitor | M. tuberculosis | Mcp-hydrolase
