5t44
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Frizzled 7 CRD== | |
| - | + | <StructureSection load='5t44' size='340' side='right' caption='[[5t44]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t44]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T44 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t44 OCA], [http://pdbe.org/5t44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t44 RCSB], [http://www.ebi.ac.uk/pdbsum/5t44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t44 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hannous, R H]] | ||
| + | [[Category: Mukund, S]] | ||
| + | [[Category: Nile, A H]] | ||
| + | [[Category: Stanger, K]] | ||
[[Category: Wang, W]] | [[Category: Wang, W]] | ||
| - | [[Category: | + | [[Category: Cysteine rich domain]] |
| - | [[Category: | + | [[Category: Immune system]] |
| - | + | ||
Revision as of 13:29, 5 April 2017
Crystal structure of Frizzled 7 CRD
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