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Cyclin

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Line 17: Line 17:
**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br />
**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br />
-
**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]] - hCYCA2 +CDK2 T160P+inhibitor<br />
+
**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5lqe]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />
-
**[[1fin]] - hCYCA2 +CDK2<br />
+
**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
**[[1vyw]] - hCYCA2 C-terminal + hCDK2<br />
**[[1vyw]] - hCYCA2 C-terminal + hCDK2<br />
**[[1jst]], [[3tnw]] - hCYCA2 +CDK2 T160P<br />
**[[1jst]], [[3tnw]] - hCYCA2 +CDK2 T160P<br />
Line 46: Line 46:
**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />
**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />
-
**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]] – hCYCC + CDK8 + inhibitor<br />
+
**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]] – hCYCC + CDK8 + inhibitor<br />
*CYCD
*CYCD
Line 55: Line 55:
*CYCE
*CYCE
-
**[[1w98]] – hCYCE1 +CDK2 T160P
+
**[[1w98]] – hCYCE1 +CDK2 T160P<br />
 +
**[[5l2w]] – hCYCE1 + CDK2 + drug<br />
*CYCH
*CYCH
Line 66: Line 67:
**[[4un0]] - hCYCK + CDK12 T160P<br />
**[[4un0]] - hCYCK + CDK12 T160P<br />
**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
-
**[[4cjy]] - hCYCK +CDK12 T160P+inhibitor<br />
+
**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
 +
**[[4cjy]], [[5acb]] - hCYCK +CDK12 T160P+inhibitor<br />
*CYCT
*CYCT
Line 72: Line 74:
**[[3blh]] - hCYCT1 +CDK9<br />
**[[3blh]] - hCYCT1 +CDK9<br />
**[[3blq]] - hCYCT1 +CDK9+ATP<br />
**[[3blq]] - hCYCT1 +CDK9+ATP<br />
-
**[[4imy]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4<br />
+
**[[4imy]], [[4or5]], [[4ogr]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4<br />
 +
**[[5l1z]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + RNA<br />
**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />
**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />
**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />
**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />
Line 87: Line 90:
*Viral CYC
*Viral CYC
-
**[[2euf]], [[2f2c]], [[2xo2]], [[1jow]] – V-CYC viral+hCDK6 – Herpesvirus<br />
+
**[[2euf]], [[2f2c]], [[2xo2]], [[1jow]] – V-CYC+hCDK6 – Herpesvirus<br />
**[[1bu2]] – V-CYC<br />
**[[1bu2]] – V-CYC<br />
**[[1xo2]] - V-CYC + hCDK6 + inhibitor<br />
**[[1xo2]] - V-CYC + hCDK6 + inhibitor<br />
-
**[[1g3n]] - V-CYC viral+hCDK6+CDK6 inhibitor<br />
+
**[[1g3n]] - V-CYC +hCDK6+CDK6 inhibitor<br />
-
**[[1f5q]] - V-CYC g viral+hCDK2
+
**[[1f5q]] - V-CYC g +hCDK2

Revision as of 08:30, 6 April 2017

Cyclin T1 (green) complex with CDK9 (cyan) and TRIS (PDB entry 3blh)

Drag the structure with the mouse to rotate

3D Structures of Cyclin

Updated on 06-April-2017

References

  1. Galderisi U, Jori FP, Giordano A. Cell cycle regulation and neural differentiation. Oncogene. 2003 Aug 11;22(33):5208-19. PMID:12910258 doi:http://dx.doi.org/10.1038/sj.onc.1206558
  2. Noble ME, Endicott JA, Brown NR, Johnson LN. The cyclin box fold: protein recognition in cell-cycle and transcription control. Trends Biochem Sci. 1997 Dec;22(12):482-7. PMID:9433129

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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