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Cytochrome P450

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Line 42: Line 42:
**[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
**[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br />
**[[3ua5]] – hP4502B6 (mutant) + amlodipine<br />
**[[3ua5]] – hP4502B6 (mutant) + amlodipine<br />
-
**[[4i91]] - hP4502B6 (mutant) + pinine<br />
+
**[[4i91]], [[4zv8]] - hP4502B6 (mutant) + pinine<br />
**[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br />
**[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br />
**[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br />
**[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br />
 +
**[[5e58]] – dwP450 2B35 + inhibitor – desert woodrat<br />
 +
**[[5e0e]] – dwP450 2B37 + inhibitor <br />
**[[2nnh]] – hP4502C8+retinoic acid<br />
**[[2nnh]] – hP4502C8+retinoic acid<br />
**[[2nni]] - hP4502C8+montelukast<br />
**[[2nni]] - hP4502C8+montelukast<br />
Line 51: Line 53:
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
**[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br />
 +
**[[5a5i]], [[5a5j]] - hP4502C9 + inhibitor<br />
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
Line 58: Line 61:
**[[4wnt]] - hP4502D6 + ajmalicine<br />
**[[4wnt]] - hP4502D6 + ajmalicine<br />
**[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br />
**[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br />
 +
**[[5tft]], [[5tfu]], [[4xry]], [[4xrz]] - hP4502D6 + Bace1 inhibitor<br />
**[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br />
**[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br />
**[[3e6i]] – hP4502E1 fragment+indazole<br />
**[[3e6i]] – hP4502E1 fragment+indazole<br />
Line 66: Line 70:
* human P450 3 family
* human P450 3 family
-
**[[2v0m]] – hP4503A4+ketoconazole<br />
+
**[[2v0m]] – hP4503A4+ anti-fungal drug<br />
-
**[[2j0d]] - hP4503A4+erythromycin<br />
+
**[[2j0d]] - hP4503A4+ antibiotic<br />
-
**[[3nxu]], [[3tjs]] - hP4503A4+ritonavir<br />
+
**[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br />
-
**[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]] - hP4503A4 (mutant) +ritonavir derivative<br />
+
**[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]] - hP4503A4 (mutant) + anti-HIV drug<br />
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[4i3q]] - hP4503A4 (mutant) <br />
**[[4i3q]] - hP4503A4 (mutant) <br />
**[[4ny4]] - hP4503A4 + inhibitor <br />
**[[4ny4]] - hP4503A4 + inhibitor <br />
 +
**[[5te8]] - hP4503A4 + sedation drug <br />
 +
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
* human P450 7 family
* human P450 7 family
Line 82: Line 88:
*human P450 11 family
*human P450 11 family
-
**[[4dvq]] - hP45011B2 + corticosterone<br />
+
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
-
**[[4fdh]] - hP45011B2 + fadrozole<br />
+
**[[4fdh]] - hP450 CYP11B2 + fadrozole<br />
 +
**[[4zgx]] - hP450 CYP11B2 + inhibitor<br />
* human P450 19 family (aromatase)
* human P450 19 family (aromatase)
Line 110: Line 117:
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450 CYP121+pyrazole derivative<br />
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450 CYP121+pyrazole derivative<br />
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br />
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br />
-
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]] - MtP450 CYP121 + inhibitor<br />
+
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]] - MtP450 CYP121 + inhibitor<br />
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br />
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br />
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
Line 117: Line 124:
**[[2wgy]] – MtP450 CYP130 (mutant)<br />
**[[2wgy]] – MtP450 CYP130 (mutant)<br />
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br />
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br />
-
**[[2uuq]] – MtP450 CYP130
+
**[[2uuq]] – MtP450 CYP130<br />
 +
**[[5hdi]] - MtP450 CYP144A1<br />
* P450cam
* P450cam
Line 127: Line 135:
**[[2h7q]] - PpP450cam+imidazole<br />
**[[2h7q]] - PpP450cam+imidazole<br />
**[[1cp4]] - PpP450cam+benzene<br />
**[[1cp4]] - PpP450cam+benzene<br />
-
**[[1akd]], [[1iwi]], [[1noo]], [[7cpp]], [[8cpp]], [[2zwt]], [[2zwu]] - PpP450cam+1S-camphor derivative<br />
+
**[[1akd]], [[1iwi]], [[1noo]], [[7cpp]], [[8cpp]], [[2zwt]], [[2zwu]], [[5ik1]] - PpP450cam+1S-camphor derivative<br />
**[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br />
**[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br />
**[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br />
**[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br />
Line 158: Line 166:
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br />
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br />
**[[2m56]] - PpP450cam + putidaredoxin + camphor <br />
**[[2m56]] - PpP450cam + putidaredoxin + camphor <br />
-
**[[3w9c]] - PpP450cam (mutant)+ putidaredoxin <br />
+
**[[3w9c]], [[5gxg]] - PpP450cam (mutant)+ putidaredoxin <br />
**[[3oft]], [[4c9m]], [[3lxh]], [[3lxi]], [[3ofu]] – NaP450 – ''Novosphignobium aromaticivorans''<br />
**[[3oft]], [[4c9m]], [[3lxh]], [[3lxi]], [[3ofu]] – NaP450 – ''Novosphignobium aromaticivorans''<br />
**[[4c9p]] - NaP450cam (mutant) + camphor <br />
**[[4c9p]] - NaP450cam (mutant) + camphor <br />
Line 178: Line 186:
*P450epoK
*P450epoK
-
**[[1pkf]] – P450epoK+epothilone D – ''Sorangium cellulosum''
+
**[[1pkf]] – ScP450epoK+epothilone D – ''Sorangium cellulosum''
*P450cin
*P450cin
-
**[[3bdz]], [[3be0]] – CbP450cin – ''Citrobacter braakii''<br />
+
**[[3bdz]], [[3be0]], [[4fyz]] – CbP450cin – ''Citrobacter braakii''<br />
-
**[[4fyz]] - CbP450cin
+
**[[4lht]], [[4l77]] - CbP450cin (mutant)<br />
 +
**[[4l6g]] – CbP450cin (mutant) + cineole<br />
* rabbit P450
* rabbit P450
-
**[[2bdm]] – rP4502B4 – rabbit<br />
+
**[[2bdm]] – rP450 CYP2B4 – rabbit<br />
-
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]] - rP4502B4 (mutant)<br />
+
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]] - rP450 CYP2B4 (mutant)<br />
-
**[[1suo]],[[3g5n]], [[3g93]], [[2q6n]], [[3tk3]] - rP4502B4 (mutant)+imidazole derivative<br />
+
**[[1suo]],[[3g5n]], [[3g93]], [[2q6n]], [[3tk3]] - rP450 CYP2B4 (mutant)+imidazole derivative<br />
-
**[[4mgj]] - rP4502B4 (mutant)+ thiol derivative<br />
+
**[[4mgj]] - rP450 CYP2B4 (mutant)+ thiol derivative<br />
-
**[[3kw4]], [[3me6]], [[3tmz]], [[4h1n]] - rP4502B4 (mutant)+anti-platelet drug<br />
+
**[[3kw4]], [[3me6]], [[3tmz]], [[4h1n]] - rP450 CYP2B4 (mutant)+anti-platelet drug<br />
-
**[[4jlt]] - rP4502B4 (mutant) + anti-depressant drug<br />
+
**[[4jlt]] - rP450 CYP CYP2B4 (mutant) + anti-depressant drug<br />
-
**[[3uas]] - rP4502B4 (mutant)+ inactivator<br />
+
**[[3uas]] - rP450 CYP CYP2B4 (mutant)+ inactivator<br />
-
**[[1dt6]] - rP4502C5 (mutant)<br />
+
**[[5t6q]] - rP450 CYP4B1 + octane<br />
-
**[[1nr6]] – rP4502C5+diclofenac<br />
+
**[[1dt6]] - rP450 CYP2C5 (mutant)<br />
-
**[[1n6b]] - rP4502C5+sulfaphenazole
+
**[[1nr6]] – rP450 CYP2C5+diclofenac<br />
 +
**[[1n6b]] - rP450 CYP2C5+sulfaphenazole
*P450 BM3
*P450 BM3
-
**[[3cbd]] – BmP450 heme domain – ''Bacillus megaterium''<br />
+
**[[3cbd]], [[2bmh]] – BmP450 heme domain – ''Bacillus megaterium''<br />
-
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]] - BmP450 heme domain (mutant)<br />
+
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]] - BmP450 heme domain (mutant)<br />
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br />
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br />
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br />
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br />
**[[1jpz]], [[1zo9]], [[1zoa]], [[4kpa]] - BmP450 heme domain + palmitate derivative<br />
**[[1jpz]], [[1zo9]], [[1zoa]], [[4kpa]] - BmP450 heme domain + palmitate derivative<br />
-
**[[1smj]] - BmP450 heme domain (mutant) + palmitoleate<br />
+
**[[1smj]], [[5jq2]] - BmP450 heme domain (mutant) + palmitate derivative<br />
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br />
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br />
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br />
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br />
Line 215: Line 225:
**[[3wsp]] - BmP450 + decoy molecule<br />
**[[3wsp]] - BmP450 + decoy molecule<br />
**[[2uwh]] - BmP450102+palmitic acid<br />
**[[2uwh]] - BmP450102+palmitic acid<br />
-
**[[3ben]] - BmP450102 + imidazole derivative<br />
+
**[[3ben]] - BmP450 heme domain + inhibitor<br />
-
**[[2j1m]], [[2j4s]] - BmP450102+DMSO<br />
+
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
**[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br />
**[[1bvy]], [[1bu7]] – BmP450102A1 FMN domain<br />
**[[1fag]] – BmP450102A1+ palmitic acid<br />
**[[1fag]] – BmP450102A1+ palmitic acid<br />
-
**[[1fah]] – BmP450102A1 (mutant)<br />
+
**[[4yt3]] - BmP450 CYP106A2 <br />
-
**[[2bmh]] - BmP450102A1<br />
+
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
 +
**[[5l90]] - BmP450 CYP109E1 <br />
 +
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
 +
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
* Other CYPs
* Other CYPs
Line 226: Line 239:
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
-
**[[1q5d]] – ScP450EPOK+epothilone – ''Sorangium cellulosum''<br />
+
**[[4oqs]] - AoP450 CYP105AS1<br />
-
**[[1q5e]] - ScP450EPOK<br />
+
**[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br />
-
**[[1io8]] – SsP450119 (mutant) – ''Sulfolobus solfataricus''<br />
+
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
-
**[[1io9]], [[1io7]], [[1f4u]] - SsP450119<br />
+
**[[5ex6]] - P450 – ''Streptomyces toyocaensis''<br />
-
**[[1f4t]] - SsP450119+ phenylimidazole<br />
+
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
-
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
+
**[[4wpz]] - SaP450 CYP107W1 – ''Streptomyces avermitilis''<br />
-
**[[1cpt]] – P450108 – ''Pseudomonas sp.''<br />
+
**[[3abb]] – SaP450 CYP105D6<br />
 +
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
 +
**[[1q5e]] - ScP450EPOK - ''Sorangium cellulosum''<br />
 +
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
 +
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
 +
**[[1cpt]] – P450 TERP – ''Pseudomonas sp.''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
-
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
 
**[[4r20]], [[4r21]] - P45017A2 – zebra fish<br />
**[[4r20]], [[4r21]] - P45017A2 – zebra fish<br />
-
**[[3aba]] – SaP450105P1+filipin I – ''Streptomyces avermitilis''<br />
 
-
**[[3abb]] – SaP450105D6<br />
 
-
**[[3e5j]], [[3e5l]] - SaP450105P1 (mutant)<br />
 
-
**[[3e5k]] - SaP450105P1 (mutant)+4-phenylimidazole<br />
 
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
-
**[[2vzm]] – SvP450107L1 (mutant)+narbomycin<br />
 
-
**[[2c7x]] - SvP450107L1+narbomycin<br />
 
-
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450107L1+YC-17<br />
 
**[[2bvj]] - SvP450107L1<br />
**[[2bvj]] - SvP450107L1<br />
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
 +
**[[4rm4]] - BsP450 CYP109B1<br />
 +
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
 +
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
 +
**[[2z3t]] - StrP450 CYP245A1 - ''Streptomyces sp.''<br />
 +
**[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
 +
**[[5liv]] - ScP450 CYP260A1 <br />
 +
**[[5hiw]] - ScP450 CYP260B1 <br />
 +
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
 +
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
 +
**[[3r9b]] – MsP450 CYP16A2 <br />
 +
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
 +
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
 +
**[[1gwi]] - ScP450 CYP154C1<br />
 +
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
 +
**[[1n97]] – TtP450 CYP175A1<br />
 +
**[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br />
 +
**[[3tkt]] – NaP450 CYP108D1<br />
 +
**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br />
 +
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
 +
**[[3a4z]] - PaP450 VDH (mutant)<br />
 +
**[[3qi8]] – P450 – synthetic<br />
 +
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
 +
**[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br />
 +
**[[4e2p]] - P450 – ''Streptococcus himastatinicus''<br />
 +
 +
*Other CYPs complexes
 +
 +
**[[1q5d]] – ScP450EPOK+epothilone <br />
 +
**[[1f4t]] - SsP450 CYP119+ phenylimidazole<br />
 +
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
 +
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
 +
**[[3aba]] – SaP450 CYP105P1+filipin I <br />
 +
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
 +
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br />
 +
**[[2vzm]] – SvP450107L1 (mutant)+narbomycin<br />
 +
**[[2c7x]] - SvP450107L1+narbomycin<br />
 +
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450107L1+YC-17<br />
**[[2zqx]] - BsP450152A1+heptanoic acid<br />
**[[2zqx]] - BsP450152A1+heptanoic acid<br />
-
**[[4rm4]] - BsP450109B1<br />
 
-
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450134A1 (mutant)<br />
 
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
-
**[[1jin]], [[1jip]] - SeP450107A1+ ketoconazole - ''Saccharopolyspora erythraea''<br />
+
**[[1jin]], [[1jip]] - SeP450107A1+ ketoconazole <br />
**[[1jio]], [[1oxa]] - SeP450107A1+6DEB<br />
**[[1jio]], [[1oxa]] - SeP450107A1+6DEB<br />
**[[1eup]] – SeP450107A1+androstendione<br />
**[[1eup]] – SeP450107A1+androstendione<br />
**[[1egy]] - SeP450107A1+aminophenanthrene<br />
**[[1egy]] - SeP450107A1+aminophenanthrene<br />
-
**[[2jjn]], [[2jjo]] - SeP450113A1 (mutant)<br />
+
**[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br />
-
**[[2jjp]] - SeP450113A1 (mutant)+ketoconazole<br />
+
**[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br />
-
**[[2xfh]] - SeP450113A1 (mutant)+clotrimazole<br />
+
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
-
**[[3a1l]] – SsP450245A1+dichlorochrompyrrolic acid – ''Streptomyces sp.''<br />
+
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
-
**[[2z3t]] - SsP450245A1<br />
+
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
-
**[[2z3u]] - SsP450245A1+chromopyrrolic acid<br />
+
**[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD <br />
-
**[[3cv8]] – SgP450105A1 (mutant) – ''Streptomyces griseolus''<br />
+
-
**[[3cv9]], [[2zbz]] - SgP450105A1 (mutant)+vitamin D3<br />
+
-
**[[2zbx]] - SgP450105A1+imidazole<br />
+
-
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
+
-
**[[2rch]], [[3dsi]] – AtP45074A+13(S)-HOD – ''Arabidopsis thaliana''<br />
+
**[[3dsj]] - AtP45074A (mutant)+13(S)-HOD<br />
**[[3dsj]] - AtP45074A (mutant)+13(S)-HOD<br />
**[[2rcl]] - AtP45074A+vernolic acid<br />
**[[2rcl]] - AtP45074A+vernolic acid<br />
**[[3dsk]] - AtP45074A (mutant)+ vernolic acid<br />
**[[3dsk]] - AtP45074A (mutant)+ vernolic acid<br />
-
**[[2rcm]], [[3cli]] - AtP45074A<br />
+
**[[3r9c]] – MsP450 CYP16A2 + econazole<br />
-
**[[3r9b]] – MsP45016A2 – ''Mycobacterium smegmatis''<br />
+
**[[2rfc]] – PtP450+phenylimidazole<br />01D2<br />
-
**[[3r9c]] – MsP45016A2 + econazole<br />
+
**[[3tkt]] – NaP450 CYP108D1<br />
-
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
+
**[[3awm]] – SpP450-α + palmitic acid <br />
-
**[[2rfc]] – PtP450+phenylimidazole<br />
+
-
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450158A1 – ''Streptomyces coelicolor''<br />
+
-
**[[1gwi]] - ScP450154C1<br />
+
-
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
+
-
**[[1n97]] – TtP450175A1<br />
+
-
**[[3nv5]], [[3nv6]], [[4dxy]] - NaP240101D2<br />
+
-
**[[3tkt]] – NaP450108D1<br />
+
-
**[[3awm]] – SpP450-α + palmitic acid – ''Sphingomonas paucimobilis''<br />
+
-
**[[3awp]], [[3awq]] - SpP450-α (mutant)<br />
+
-
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
+
-
**[[3a4z]] - PaP450 VDH (mutant)<br />
+
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
-
**[[3qi8]] – P450 – synthetic<br />
+
**[[4do1]], [[4egm]] – RpP450 CYP199A4 + benzoate derivative<br />
-
**[[4dnz]] – RpP450199A4 – ''Rhodopseudomonas palustris''<br />
+
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
-
**[[4do1]], [[4egm]] – RpP450199A4 + benzoate derivative<br />
+
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
-
**[[4egn]] – RpP450199A4 + veratric acid<br />
+
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
-
**[[4egp]] – RpP450199A4 + naphthoic acid<br />
+
-
**[[4ego]] – RpP450199A4 + indole derivative<br />
+
-
**[[3o1a]] – P450 165D3 – ''Actinoplanes teichomyceticus''<br />
+
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br />
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br />
-
**[[4e2p]] - P450 – ''Streptococcus himastatinicus''<br />
+
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
 +
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
 +
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:29, 9 April 2017

Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5)

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3D Structures of Cytochrome P450

Updated on 09-April-2017

References

  1. ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
  2. ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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