1ubd
From Proteopedia
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|PDB= 1ubd |SIZE=350|CAPTION= <scene name='initialview01'>1ubd</scene>, resolution 2.500Å | |PDB= 1ubd |SIZE=350|CAPTION= <scene name='initialview01'>1ubd</scene>, resolution 2.500Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ubd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ubd OCA], [http://www.ebi.ac.uk/pdbsum/1ubd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ubd RCSB]</span> | ||
}} | }} | ||
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[[Category: Shenk, T.]] | [[Category: Shenk, T.]] | ||
[[Category: Usheva, A.]] | [[Category: Usheva, A.]] | ||
| - | [[Category: ZN]] | ||
[[Category: complex (transcription regulation/dna)]] | [[Category: complex (transcription regulation/dna)]] | ||
[[Category: dna- protein recognition]] | [[Category: dna- protein recognition]] | ||
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[[Category: zinc finger protein]] | [[Category: zinc finger protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:57 2008'' |
Revision as of 21:08, 30 March 2008
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| , resolution 2.500Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT
Overview
Ying-Yang 1 protein (YY1) supports specific, unidirectional initiation of messenger RNA production by RNA polymerase II from two adjacent start sites in the adeno-associated virus P5 promoter, a process which is independent of the TATA box-binding protein (TBP). The 2.5-A resolution YY1-initiator element cocrystal structure reveals four zinc fingers recognizing a YY1-binding consensus sequence. Upstream of the transcription start sites protein-DNA contacts involve both strands and downstream they are virtually restricted to the template strand, permitting access to the active center of RNA polymerase II and ensuring specificity and directionality. The observed pattern of protein-DNA contacts also explains YY1 binding to a preformed transcription bubble, and YY1 binding to a DNA/RNA hybrid analog of the P5 promoter region containing a nascent RNA transcript. A model is proposed for YY1-directed, TBP-independent transcription initiation.
About this Structure
1UBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator., Houbaviy HB, Usheva A, Shenk T, Burley SK, Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13577-82. PMID:8942976
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