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5jfc

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'''Unreleased structure'''
 
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The entry 5jfc is ON HOLD until Paper Publication
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==NADH-dependent Ferredoxin:NADP Oxidoreductase (NfnI) from Pyrococcus furiosus==
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<StructureSection load='5jfc' size='340' side='right' caption='[[5jfc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Zadvornyy, O.A., Schut, G.J., Nguyen, D.M., Artz, J.H., Tokmina-Lukaszewska, M., Lipscomb, G., King, P.W., Adams, M.W., Peters, J.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5jfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JFC FirstGlance]. <br>
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Description: NADH-dependent Ferredoxin:NADP Oxidoreductase (NfnI) from Pyrococcus furiosus
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jca|5jca]]</td></tr>
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[[Category: Nguyen, D.M]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(P)(+)_transhydrogenase_(ferredoxin) NAD(P)(+) transhydrogenase (ferredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.1.4 1.6.1.4] </span></td></tr>
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[[Category: Schut, G.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jfc OCA], [http://pdbe.org/5jfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jfc RCSB], [http://www.ebi.ac.uk/pdbsum/5jfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jfc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SUDHA_PYRFU SUDHA_PYRFU]] A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor. Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin. Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen. Does not reduce fumarate, succinate, nitrate, nitrite, sulfate, sulfite or protons. Does not possess any hydrogenase activity or NADPH-dependent glutamate synthase activity.<ref>PMID:10968624</ref> <ref>PMID:7961401</ref> [REFERENCE:4] [[http://www.uniprot.org/uniprot/SUDHB_PYRFU SUDHB_PYRFU]] A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor. Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin. Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen. Does not reduce fumarate, succinate, nitrate, nitrite, sulfate, sulfite or protons. Does not possess any hydrogenase activity or NADPH-dependent glutamate synthase activity.<ref>PMID:10968624</ref> <ref>PMID:7961401</ref> <ref>PMID:7961401</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Pyrococcus furiosus]]
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[[Category: Adams, M W]]
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[[Category: Artz, J H]]
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[[Category: King, P W]]
[[Category: Lipscomb, G]]
[[Category: Lipscomb, G]]
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[[Category: King, P.W]]
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[[Category: Nguyen, D M]]
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[[Category: Adams, M.W]]
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[[Category: Peters, J W]]
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[[Category: Peters, J.W]]
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[[Category: Schut, G J]]
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[[Category: Zadvornyy, O.A]]
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[[Category: Artz, J.H]]
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[[Category: Tokmina-Lukaszewska, M]]
[[Category: Tokmina-Lukaszewska, M]]
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[[Category: Zadvornyy, O A]]
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[[Category: Nfni]]
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[[Category: Oxidoreductase]]

Revision as of 11:43, 12 April 2017

NADH-dependent Ferredoxin:NADP Oxidoreductase (NfnI) from Pyrococcus furiosus

5jfc, resolution 1.60Å

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