5jih
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19)== | |
| - | + | <StructureSection load='5jih' size='340' side='right' caption='[[5jih]], [[Resolution|resolution]] 1.66Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jik|5jik]], [[5jii|5jii]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jih OCA], [http://pdbe.org/5jih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jih RCSB], [http://www.ebi.ac.uk/pdbsum/5jih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jih ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Djinovic-Carugo, K]] | ||
| + | [[Category: Humm, A]] | ||
| + | [[Category: Lobner, E]] | ||
| + | [[Category: Mlynek, G]] | ||
| + | [[Category: Obinger, C]] | ||
| + | [[Category: Antibody engineering]] | ||
| + | [[Category: Ch3 domain]] | ||
| + | [[Category: Erbb-2]] | ||
| + | [[Category: Fc fragment]] | ||
| + | [[Category: Fcab]] | ||
| + | [[Category: Glycosylation]] | ||
| + | [[Category: Her2]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunoglobulin g1]] | ||
Revision as of 11:43, 12 April 2017
Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19)
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Categories: Djinovic-Carugo, K | Humm, A | Lobner, E | Mlynek, G | Obinger, C | Antibody engineering | Ch3 domain | Erbb-2 | Fc fragment | Fcab | Glycosylation | Her2 | Immune system | Immunoglobulin g1
