5tbx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==hnRNP A18 RNA Recognition Motif== | |
| - | + | <StructureSection load='5tbx' size='340' side='right' caption='[[5tbx]], [[Resolution|resolution]] 1.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TBX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbx OCA], [http://pdbe.org/5tbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tbx RCSB], [http://www.ebi.ac.uk/pdbsum/5tbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbx ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN]] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aligholizadeh, E]] | ||
| + | [[Category: Coburn, K M]] | ||
[[Category: Melville, Z]] | [[Category: Melville, Z]] | ||
| - | [[Category: | + | [[Category: Roth, B M]] |
| - | [[Category: Varney, K | + | [[Category: Varney, K M]] |
| - | [[Category: Weber, D | + | [[Category: Weber, D J]] |
| - | [[Category: | + | [[Category: Rna binding protein]] |
| + | [[Category: Rna-binding protein]] | ||
Revision as of 11:46, 12 April 2017
hnRNP A18 RNA Recognition Motif
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