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Sandbox GGC2
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== Structure == | == Structure == | ||
Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain</scene> and a <scene name='75/752269/Large_domain_green/1'>large domain</scene>. | Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain</scene> and a <scene name='75/752269/Large_domain_green/1'>large domain</scene>. | ||
| + | At the <scene name='75/752269/Gkactivesite_glucose/2'>active site</scene> of glucoskinase, glucose molecule form hydrogen bonds with Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290. At the allosteric site, either glucokinase activators (GKA) or glucokinase inhibitor (GKI)will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site. | ||
== Function == | == Function == | ||
Revision as of 23:49, 17 April 2017
Glucokinase
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
