Dethiobiotin synthetase

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	**[[3fmf]] – MtDTBS + DAN<br />		**[[3fmf]] – MtDTBS + DAN<br />
		+	**[[4wop]] - MtDTBS + CTP<br />
		+	**[[3fmi]] – MtDTBS + aminopelargonic acid<br />
	**[[1dad]] – EcDTBS + ADP<BR />		**[[1dad]] – EcDTBS + ADP<BR />
	**[[1dae]] - EcDTBS + nonanedioate derivative<br />		**[[1dae]] - EcDTBS + nonanedioate derivative<br />
-	**[[3fmi]] – MtDTBS + aminopelargonic acid<br />
	**[[1dai]] - EcDTBS + DAN		**[[1dai]] - EcDTBS + DAN

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Revision as of 07:04, 18 April 2017

spinqualitylabelsall models Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry 1a82) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Dethiobiotin synthetase (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.[1] Structural highlights The .[2]

3D dethiobiotin synthetase

Updated on 18-April-2017

References

1. ↑ Krell K, Eisenberg MA. The purification and properties of dethiobiotin synthetase. J Biol Chem. 1970 Dec 25;245(24):6558-66. PMID:4921568
2. ↑ Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5495-500. PMID:9576910