Trichodiene synthase

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== Structural highlights ==
== Structural highlights ==
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The active site of TCS contains diphosphate, the competitive inhibitor benzyl-diethylethanaminium and Mg+2 ions<ref>PMID:17678871</ref>.
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The <scene name='54/542259/Cv/4'>active site</scene> of TCS contains <scene name='54/542259/Cv/5'>diphosphate, the competitive inhibitor benzyl-diethylethanaminium and Mg+2 ions</scene><ref>PMID:17678871</ref>.
</StructureSection>
</StructureSection>

Revision as of 10:28, 18 April 2017

Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) 2q9y

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3D Structures of trichodiene synthase

Updated on 18-April-2017

1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium

References

  1. ↑ Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326
  2. ↑ Vedula LS, Zhao Y, Coates RM, Koyama T, Cane DE, Christianson DW. Exploring biosynthetic diversity with trichodiene synthase. Arch Biochem Biophys. 2007 Oct 15;466(2):260-6. Epub 2007 Jun 28. PMID:17678871 doi:10.1016/j.abb.2007.06.016

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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