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2w0t

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Revision as of 06:19, 19 April 2017

Solution structure of the FCS zinc finger domain of human LMBL2

Structural highlights

2w0t is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LMBL2_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Polycomb group proteins are epigenetic regulators that maintain patterns of gene expression over multiple rounds of cell division. Many of these proteins, including polyhomeotic and the MBT repeat containing proteins SCM and dSfmbt, contain an atypical C2C2 zinc finger with a characteristic phenylalanine-cysteine-serine sequence motif. The reoccurrence of this so-called FCS zinc finger in a variety of polycomb group proteins suggests that it has an important regulatory function. We have determined the solution structure of the FCS zinc finger of the human dSfmbt homologue L(3)mbt-like 2 (L3MBTL2). The structure consists of a beta-hairpin followed by an alpha-helix. The zinc ligands are situated in the beta-hairpin and at the N-terminus of the alpha-helix an arrangement typical of the treble clef class of zinc fingers. The structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs.

Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2.,Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M Protein Sci. 2009 Mar;18(3):657-61. PMID:19241375^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Nucleic Acids Res. 2009 Apr;37(7):2204-10. Epub 2009 Feb 20. PMID:19233876 doi:10.1093/nar/gkp086
↑ Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M. Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2. Protein Sci. 2009 Mar;18(3):657-61. PMID:19241375 doi:10.1002/pro.51

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w0t"

@@ Line 1: / Line 1: @@
-==SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2==
+==Solution structure of the FCS zinc finger domain of human LMBL2==
 <StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
 [[Category: Allen, M D]]
 [[Category: Bycroft, M]]
 [[Category: Lechtenberg, B C]]
+[[Category: Alternative splicing]]
 [[Category: Chromatin regulator]]
 [[Category: Lmbl2]]
@@ Line 45: / Line 45: @@
 [[Category: Phosphoprotein]]
 [[Category: Polycomb group]]
+[[Category: Polymorphism]]
 [[Category: Rna binding]]
 [[Category: Transcription]]
@@ Line 50: / Line 51: @@
 [[Category: Treble clef fold]]
 [[Category: Yacg]]
+[[Category: Zinc]]
 [[Category: Zinc-finger]]

2w0t

From Proteopedia

Revision as of 06:19, 19 April 2017

Solution structure of the FCS zinc finger domain of human LMBL2

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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