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1ukl

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|PDB= 1ukl |SIZE=350|CAPTION= <scene name='initialview01'>1ukl</scene>, resolution 3.00&Aring;
|PDB= 1ukl |SIZE=350|CAPTION= <scene name='initialview01'>1ukl</scene>, resolution 3.00&Aring;
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ukl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukl OCA], [http://www.ebi.ac.uk/pdbsum/1ukl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ukl RCSB]</span>
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[[Category: transcription factor]]
[[Category: transcription factor]]
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Revision as of 21:11, 30 March 2008

Image:1ukl.jpg


PDB ID 1ukl

Drag the structure with the mouse to rotate
, resolution 3.00Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Importin-beta and SREBP-2 complex


Overview

The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through a direct interaction of its helix-loop-helix leucine zipper domain with importin-beta. We show the crystal structure of importin-beta complexed with the active form of SREBP-2. Importin-beta uses characteristic long helices like a pair of chopsticks to interact with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a pseudo-twofold symmetry on its surface structure so that it can accommodate a symmetric dimer molecule. Importin-beta may use a similar strategy to recognize other dimeric cargoes.

About this Structure

1UKL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor., Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y, Science. 2003 Nov 28;302(5650):1571-5. PMID:14645851

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