DNA ligase
From Proteopedia
(Difference between revisions)
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**[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br /> | **[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br /> | ||
**[[1a0i]] – LigD + ATP – Bacteriophage T7<br /> | **[[1a0i]] – LigD + ATP – Bacteriophage T7<br /> | ||
| - | **[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus'' | + | **[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br /> |
| + | **[[4d05]] – LigD + AMP - ''Psychromonas'' <br /> | ||
*NAD+-dependent LigD | *NAD+-dependent LigD | ||
| - | **[[3jsl]], [[3jsn]] - | + | **[[3jsl]], [[3jsn]] - SaLigD adenylation domain – ''Staphylococcus aureus''<br /> |
| + | **[[4cc5]], [[4cc6]], [[5fpo]], [[5fpr]] – SaLigD adenylation domain + inhibitor <br /> | ||
**[[3ba8]], [[3ba9]], [[3baa]], [[3bab]], [[3bac]], [[4eeq]], [[4efb]], [[4efe]], [[4lh6]], [[4lh7]] - EfLigD adenylation domain + NMN + inhibitor – ''Enterococcus faecalis''<br /> | **[[3ba8]], [[3ba9]], [[3baa]], [[3bab]], [[3bac]], [[4eeq]], [[4efb]], [[4efe]], [[4lh6]], [[4lh7]] - EfLigD adenylation domain + NMN + inhibitor – ''Enterococcus faecalis''<br /> | ||
**[[1ta8]], [[1tae]] - EfLigD adenylation domain<br /> | **[[1ta8]], [[1tae]] - EfLigD adenylation domain<br /> | ||
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**[[1b04]] – LigD adenylation domain (mutant) – ''Geobacillus stearothermophilus''<br /> | **[[1b04]] – LigD adenylation domain (mutant) – ''Geobacillus stearothermophilus''<br /> | ||
**[[4glw]] – LigD A + NMN + inhibitor – ''Streptococcus pneumoniae''<br /> | **[[4glw]] – LigD A + NMN + inhibitor – ''Streptococcus pneumoniae''<br /> | ||
| - | **[[4glx]] – | + | **[[4glx]] – EcLigD + DNA + inhibitor - ''Escherichia coli''<br /> |
| + | **[[5tt5]] - EciLigD + NAD<br /> | ||
| + | **[[3pn1]], [[4uco]], [[4ucr]], [[4ucs]], [[4uct]], [[4ucu]], [[4ucv]], [[4ufz]] – HiLigD adenylation domain + inhibitor – Haemophilus influenza<br /> | ||
| + | **[[3uq8]] - HiLigD adenylation domain + NAD<br /> | ||
*LigD | *LigD | ||
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**[[2owo]] – LigD + DNA + AMP + CMP – ''Escherichia coli''<br /> | **[[2owo]] – LigD + DNA + AMP + CMP – ''Escherichia coli''<br /> | ||
**[[3qwu]] – LigD – ''Aquifex aeolicus''<br /> | **[[3qwu]] – LigD – ''Aquifex aeolicus''<br /> | ||
| - | **[[3pn1]] – HiLigD adenylation domain + inhibitor – ''Haemophilus influenzae''<br /> | ||
| - | **[[3uq8]] - HiLigD adenylation domain + NAD<br /> | ||
**[[1l7b]] – LigD BRCT domain – ''Thermos thermophilus'' - NMR<br /> | **[[1l7b]] – LigD BRCT domain – ''Thermos thermophilus'' - NMR<br /> | ||
| - | **[[3rr5]] – LigD - ''Thermococcus'' | + | **[[3rr5]] – LigD - ''Thermococcus''<br /> |
| + | **[[5frq]] - LigD + DNA polymerase III subunit β – ''Helicobacter pylori''<br /> | ||
*Mammalian LigD I | *Mammalian LigD I | ||
Revision as of 09:19, 24 April 2017
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3D Structures of DNA ligase
Updated on 24-April-2017
References
- ↑ Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell. 2006 Oct 20;24(2):279-91. PMID:17052461 doi:10.1016/j.molcel.2006.08.015
Elevated expression of DNA ligase I in human cancers., Sun DY, Urrabaz R, Nguyen M, Marty J, Stringer S, Cruz E, Medina-Gundrum L, Weitman S., Clinical Cancer Research. 2001; 7(12):4143-4148.
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene., Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW., Cancer Research. 2002; 62(14):4065-4074.
- Created with the participation of Audrey Kuan.
