1urn
From Proteopedia
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|PDB= 1urn |SIZE=350|CAPTION= <scene name='initialview01'>1urn</scene>, resolution 1.920Å | |PDB= 1urn |SIZE=350|CAPTION= <scene name='initialview01'>1urn</scene>, resolution 1.920Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1urn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urn OCA], [http://www.ebi.ac.uk/pdbsum/1urn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1urn RCSB]</span> | ||
}} | }} | ||
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[[Category: Oubridge, C.]] | [[Category: Oubridge, C.]] | ||
[[Category: Teo, C H.]] | [[Category: Teo, C H.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: GOL]] | ||
[[Category: hairpin loop]] | [[Category: hairpin loop]] | ||
[[Category: overhanging base]] | [[Category: overhanging base]] | ||
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[[Category: single strand]] | [[Category: single strand]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:13 2008'' |
Revision as of 21:14, 30 March 2008
| |||||||
| , resolution 1.920Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
U1A MUTANT/RNA COMPLEX + GLYCEROL
Overview
The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the surface of the beta-sheet as an open structure, and the AUUGCAC sequence of the loop interacts extensively with the conserved RNP1 and RNP2 motifs and the C-terminal extension of the RNP domain. These interactions include stacking of RNA bases with aromatic side chains of proteins and many direct and water-mediated hydrogen bonds. The structure reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.
About this Structure
1URN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237
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