DXP reductoisomerase
From Proteopedia
(Difference between revisions)
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**[[2jcy]] – MtDXR (mutant) <br /> | **[[2jcy]] – MtDXR (mutant) <br /> | ||
**[[4zn6]] – DXR – ''Acinetobacter baumannii'' <br /> | **[[4zn6]] – DXR – ''Acinetobacter baumannii'' <br /> | ||
| + | **[[4zqe]] – McDXR – ''Moraxella catarrhalis''<br /> | ||
*DXP reductoisomerase binary complex | *DXP reductoisomerase binary complex | ||
| Line 36: | Line 37: | ||
**[[3zhz]] – MtDXR + anti-malaria drug<br /> | **[[3zhz]] – MtDXR + anti-malaria drug<br /> | ||
**[[1ono]] – EcDXR + Mn<br /> | **[[1ono]] – EcDXR + Mn<br /> | ||
| - | **[[3iie]] – | + | **[[3iie]] – YpDXR + Mg – ''Yersinia pestis''<br /> |
| + | **[[5dul]] – YpDXR + NADPH<br /> | ||
*DXP reductoisomerase ternary complex | *DXP reductoisomerase ternary complex | ||
| Line 49: | Line 51: | ||
**[[3a14]] – TmDXR + NADPH + Mg – ''Thermotoga maritima''<br /> | **[[3a14]] – TmDXR + NADPH + Mg – ''Thermotoga maritima''<br /> | ||
**[[3au8]] – PfDXR + NADPH + Mn – ''Plasmodium falciparum''<br /> | **[[3au8]] – PfDXR + NADPH + Mn – ''Plasmodium falciparum''<br /> | ||
| - | **[[4y67]], [[4y6p]], [[4y6r]], [[4y6s]] – PfDXR + Mn + anti-malaria drug<br /> | + | **[[4y67]], [[4y6p]], [[4y6r]], [[4y6s]], [[5jaz]], [[5jbi]], [[5jc1]], [[5jmp]], [[5jmw]], [[5jnl]], [[5jo0]] – PfDXR + Mn + anti-malaria drug<br /> |
| + | **[[4zqf]] – McDXR + Mg + anti-malaria drug<br /> | ||
*DXP reductoisomerase quaternary complex | *DXP reductoisomerase quaternary complex | ||
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**[[4gae]] – PfDXR (mutant) + NADPH + Mn + pyridine inhibitor <br /> | **[[4gae]] – PfDXR (mutant) + NADPH + Mn + pyridine inhibitor <br /> | ||
**[[3wqq]], [[3wqr]], [[3wqs]] – PfDXR + NADPH + Mg + inhibitor <br /> | **[[3wqq]], [[3wqr]], [[3wqs]] – PfDXR + NADPH + Mg + inhibitor <br /> | ||
| - | + | **[[4zqg]] – McDXR + NAD + Mg + anti-malaria drug<br /> | |
| + | **[[4zqh]] – McDXR + NADPH + Mg + anti-malaria drug<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 06:41, 27 April 2017
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3D Structures of DXP reductoisomerase
Updated on 27-April-2017
References
- ↑ Takahashi S, Kuzuyama T, Watanabe H, Seto H. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9879-84. PMID:9707569
- ↑ Jansson AM, Wieckowska A, Bjorkelid C, Yahiaoui S, Sooriyaarachchi S, Lindh M, Bergfors T, Dharavath S, Desroses M, Suresh S, Andaloussi M, Nikhil R, Sreevalli S, Srinivasa BR, Larhed M, Jones TA, Karlen A, Mowbray SL. DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. J Med Chem. 2013 Aug 8;56(15):6190-9. doi: 10.1021/jm4006498. Epub 2013 Jul 17. PMID:23819803 doi:http://dx.doi.org/10.1021/jm4006498
