1usk
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1usk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1usk OCA], [http://www.ebi.ac.uk/pdbsum/1usk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1usk RCSB]</span> | ||
}} | }} | ||
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[[Category: Mowbray, S L.]] | [[Category: Mowbray, S L.]] | ||
[[Category: Salopek-Sondi, B.]] | [[Category: Salopek-Sondi, B.]] | ||
| - | [[Category: LEU]] | ||
[[Category: abc transport system]] | [[Category: abc transport system]] | ||
[[Category: leucine-binding protein]] | [[Category: leucine-binding protein]] | ||
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[[Category: x-ray crystallography]] | [[Category: x-ray crystallography]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:34 2008'' |
Revision as of 21:14, 30 March 2008
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| , resolution 2.00Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
L-LEUCINE-BINDING PROTEIN WITH LEUCINE BOUND
Overview
The periplasmic leucine-binding protein is the primary receptor for the leucine transport system in Escherichia coli. We report here the structure of an open ligand-free form solved by molecular replacement and refined at 1.5-A resolution. In addition, two closed ligand-bound structures of the same protein are presented, a phenylalanine-bound form at 1.8 A and a leucine-bound structure at a nominal resolution of 2.4 A. These structures show the basis of this protein's ligand specificity, as well as illustrating the conformational changes that are associated with ligand binding. Comparison with earlier structures provides further information about solution conformations, as well as the different specificity of the closely related leucine/isoleucine/valine-binding protein.
About this Structure
1USK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
X-ray structures of the leucine-binding protein illustrate conformational changes and the basis of ligand specificity., Magnusson U, Salopek-Sondi B, Luck LA, Mowbray SL, J Biol Chem. 2004 Mar 5;279(10):8747-52. Epub 2003 Dec 12. PMID:14672931
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