5lb7
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex structure between p60N/p80C katanin and a peptide derived from ASPM== | |
| - | + | <StructureSection load='5lb7' size='340' side='right' caption='[[5lb7]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lb7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LB7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Microtubule-severing_ATPase Microtubule-severing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.3 3.6.4.3] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lb7 OCA], [http://pdbe.org/5lb7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lb7 RCSB], [http://www.ebi.ac.uk/pdbsum/5lb7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lb7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KTNB1_MOUSE KTNB1_MOUSE]] Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.[HAMAP-Rule:MF_03022] [[http://www.uniprot.org/uniprot/ASPM_MOUSE ASPM_MOUSE]] Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis.<ref>PMID:12355089</ref> <ref>PMID:9819352</ref> [[http://www.uniprot.org/uniprot/KTNA1_MOUSE KTNA1_MOUSE]] Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity).[HAMAP-Rule:MF_03023] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Microtubule-severing ATPase]] | ||
| + | [[Category: Capitani, G]] | ||
| + | [[Category: Kammerer, R A]] | ||
| + | [[Category: Rezabkova, L]] | ||
| + | [[Category: Steinmetz, M O]] | ||
| + | [[Category: Aspm]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Katanin]] | ||
| + | [[Category: Severing enzyme]] | ||
Revision as of 13:59, 27 April 2017
Complex structure between p60N/p80C katanin and a peptide derived from ASPM
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