5nnx

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m (Protected "5nnx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5nnx is ON HOLD until Paper Publication
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==TEAD1 bound to DNA==
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<StructureSection load='5nnx' size='340' side='right' caption='[[5nnx]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
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Authors: Morgunova, E., Jolma, A., Yin, Y., Popov, A., Taipale, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nnx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNX FirstGlance]. <br>
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Description: TEAD1 bound to DNA
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnx OCA], [http://pdbe.org/5nnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnx RCSB], [http://www.ebi.ac.uk/pdbsum/5nnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnx ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[http://omim.org/entry/108985 108985]]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref> <ref>PMID:20123905</ref> <ref>PMID:15016762</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Jolma, A]]
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[[Category: Morgunova, E]]
[[Category: Popov, A]]
[[Category: Popov, A]]
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[[Category: Taipale, J]]
[[Category: Yin, Y]]
[[Category: Yin, Y]]
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[[Category: Jolma, A]]
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[[Category: Dna binding]]
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[[Category: Taipale, J]]
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[[Category: Transcription]]
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[[Category: Morgunova, E]]
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[[Category: Transcription factor]]

Revision as of 14:00, 27 April 2017

TEAD1 bound to DNA

5nnx, resolution 3.29Å

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