Endonuclease

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Line 60: Line 60:
**[[2abk]], [[1ako]] - EcENN – ''Escherichia coli''<br />
**[[2abk]], [[1ako]] - EcENN – ''Escherichia coli''<br />
-
**[[1orn]], [[1orp]], [[1p59]] - GsENN + DNA – ''Geobacillus stearothermophilus''
+
**[[1orn]], [[1orp]], [[1p59]] - GsENN + DNA – ''Geobacillus stearothermophilus''<br />
 +
**[[4unf]] – DrENN-1 – ''Deinococcus radiodurans'' <br />
 +
**[[4uob]] – DrENN-3 <br />
*ENN-IV
*ENN-IV
Line 111: Line 113:
**[[4wj0]] – PhCas1 - ''Pyrococcus horikoshii''<br />
**[[4wj0]] – PhCas1 - ''Pyrococcus horikoshii''<br />
**[[4xtk]] – TmCas1<br />
**[[4xtk]] – TmCas1<br />
 +
**[[5fcl]] – Cas1 - ''Pectobacterium atrosepticum''<br />
 +
**[[4zkj]] - SpCas1 – ''Streptococcus pyogenes''<br />
**[[3oq2]] – Cas2 – ''Desulfovibrio vulgaris''<br />
**[[3oq2]] – Cas2 – ''Desulfovibrio vulgaris''<br />
**[[4mak]] – EcCas2<br />
**[[4mak]] – EcCas2<br />
**[[4p6i]], [[4qdl]] – EcCas1 + EcCas2<br />
**[[4p6i]], [[4qdl]] – EcCas1 + EcCas2<br />
 +
**[[5dlj]], [[5dqt]], [[5dqu]], [[5dqz]], [[5ds4]], [[5ds5]], [[5ds6]] – EcCas1 + EcCas2 + DNA<br />
**[[3s4l]] – MjCas3 – ''Methanocaldococcus jannaschii''<br />
**[[3s4l]] – MjCas3 – ''Methanocaldococcus jannaschii''<br />
**[[4qqw]] – TfCas3 – ''Thermobifida fusca''<br />
**[[4qqw]] – TfCas3 – ''Thermobifida fusca''<br />
Line 126: Line 131:
**[[4ilr]], [[3zfv]] – SsCas6 <br />
**[[4ilr]], [[3zfv]] – SsCas6 <br />
**[[3i4h]] – PfCas6 - ''Pyrococcus furiosus''<br />
**[[3i4h]] – PfCas6 - ''Pyrococcus furiosus''<br />
 +
**[[5uz9]] – PaCsa5f + Cas7f + Cas8f + anti-crispr protein + RNA<br />
**[[3pkm]] – PfCas6 + RNA<br />
**[[3pkm]] – PfCas6 + RNA<br />
**[[4dzd]] – EcCas6e<br />
**[[4dzd]] – EcCas6e<br />
Line 131: Line 137:
**[[2xli]], [[2xlj]], [[2xlk]], [[4al7]] – PaCas6f (Csy4) + RNA <br />
**[[2xli]], [[2xlj]], [[2xlk]], [[4al7]] – PaCas6f (Csy4) + RNA <br />
**[[4al5]], [[4al6]] - PaCas6f (Csy4) (mutant) + RNA <br />
**[[4al5]], [[4al6]] - PaCas6f (Csy4) (mutant) + RNA <br />
-
**[[4cmp]], [[4cmq]] – SpCas9 (Csn1)<br />
+
**[[4qr0]], [[4qr1]], [[4cmp]], [[4cmq]] - SpCas9 <br />
-
**[[4oo8]], [[4un3]], [[4un4]], [[4un5]] - SpCas9 (Csn1) (mutant) + RNA + DNA<br />
+
**[[4zt0]] - SpCas9 + RNA <br />
-
**[[4ogc]], [[4oge]] – Cas9 II-C – Actinomyces naeslundii<br />
+
**[[4zt9]] - SpCas9 (mutant) + RNA <br />
 +
**[[5f9r]] - SpCas9 + RNA + DNA<br />
 +
**[[4oo8]], [[4un3]], [[4un4]], [[4un5]], [[5fw1]], [[5fw2]], [[5fw3]], [[5fq5]], [[5b2r]], [[5b2s]], [[5b2t]] - SpCas9 (Csn1) (mutant) + RNA + DNA<br />
 +
**[[4ogc]], [[4oge]] – Cas9 II-C – ''Actinomyces naeslundii''<br />
 +
**[[5x2h]], [[5x2g]] – Cas9 + RNA + DNA – ''Campylobacter jejuni''<br />
 +
**[[5czz]] - SaCas9 (Csn1) + RNA + DNA - ''Staphylococcus aureus''<br />
 +
**[[5axw]] - SaCas9 (Csn1) (mutant) + RNA + DNA <br />
 +
**[[5b2o]], [[5b2p]], [[5b2q]] - FtCas9 (mutant) + RNA + DNA – ''Francisella tularensis''<br />
**[[3ung]], [[3ur3]], [[4doz]], [[4w8y]] – PfCas10 CMR2 subunit <br />
**[[3ung]], [[3ur3]], [[4doz]], [[4w8y]] – PfCas10 CMR2 subunit <br />
**[[4h4k]] – PfCas10 CMR2+CMR3 subunits <br />
**[[4h4k]] – PfCas10 CMR2+CMR3 subunits <br />
Line 150: Line 163:
**[[3toc]], [[3v7f]] – SpCsn2<br />
**[[3toc]], [[3v7f]] – SpCsn2<br />
**[[3ps0]] – SsCsa2<br />
**[[3ps0]] – SsCsa2<br />
 +
**[[5wqe]] – AaCas C2C1 + RNA – ''Alicyclobacillus acidoterrestris''<br />
 +
**[[5u34]] – AaCas C2C1 (mutant) + RNA <br />
 +
**[[5u30]], [[5u31]], [[5u33]] – AaCas C2C1 + RNA + DNA<br />
 +
**[[5kk5]], [[5b43]] – Cas Cpf1 + RNA + DNA – ''Acidaminococcus''<br />
*EcoKI ENN
*EcoKI ENN
Line 175: Line 192:
**[[1rve]], [[1az3]] – EcENN<br />
**[[1rve]], [[1az3]] – EcENN<br />
**[[1az4]] - EcENN (mutant) <br />
**[[1az4]] - EcENN (mutant) <br />
-
**[[2rve]], [[4rve]], [[1rva]], [[1rvb]], [[1rvc]], [[1az0]], [[1bsu]], [[1bua]], [[1bgb]], [[1rv5]], [[1b94]], [[1b95]], [[1eo3]], [[1eo4]], [[1eon]], [[1eoo]], [[1eop]], [[2b0d]], [[2b0e]] - EcENN + DNA<br />
+
**[[2rve]], [[4rve]], [[1rva]], [[1rvb]], [[1rvc]], [[1az0]], [[1bsu]], [[1bua]], [[1bgb]], [[1rv5]], [[1b94]], [[1b95]], [[1eo3]], [[1eo4]], [[1eon]], [[1eoo]], [[1eop]], [[2b0d]], [[2b0e]], [[4orj]], [[5hlk]] - EcENN + DNA<br />
-
**[[1bss]], [[1b96]], [[1b97]], [[1stx]], [[1suz]], [[1sx5]], [[1sx8]], [[2ge5]] - EcENN (mutant) + DNA
+
**[[1bss]], [[1b96]], [[1b97]], [[1stx]], [[1suz]], [[1sx5]], [[1sx8]], [[2ge5]] - EcENN (mutant) + DNA<br />
 +
**[[5f8a]] - EcENN + DNA + Lu<br />
*BamHI ENN
*BamHI ENN
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**[[3ory]]– ENN – ''Desulfurococcus amylolyticus''<br />
**[[3ory]]– ENN – ''Desulfurococcus amylolyticus''<br />
**[[3q8k]], [[3q8l]], [[3q8m]] - hENN + DNA<br />
**[[3q8k]], [[3q8l]], [[3q8m]] - hENN + DNA<br />
 +
**[[5fv7]] - hENN + inhibitor<br />
**[[1rxv]], [[1rxw]] - AfENN + DNA<br />
**[[1rxv]], [[1rxw]] - AfENN + DNA<br />
**[[1ul1]] - hENN + PCNA <br />
**[[1ul1]] - hENN + PCNA <br />
Line 316: Line 335:
**[[3bm3]] – ENN – ''Pyrococcus''
**[[3bm3]] – ENN – ''Pyrococcus''
-
*NHN ENN
+
*HNH ENN
-
**[[4h6d]] – ENN – ''Geobacter metallireducens''
+
**[[4h6d]] – ENN – ''Geobacter metallireducens''<br />
 +
**[[5h0o]], [[5h0m]] – ENN – Geobacillus virus E2<br />
*UV damage ENN
*UV damage ENN
Line 334: Line 354:
*BpujI ENN
*BpujI ENN
-
**[[2vla]], [[3s1s]] – ENN – ''Bacillus pumilus''
+
**[[2vla]], [[3s1s]] – BpENN – ''Bacillus pumilus''<br />
 +
**[[5hnf]], [[5hnh]], [[5hlt]] – BpENN + DNA <br />
*Sau3AI ENN
*Sau3AI ENN
-
**[[2reu]] – ENN C terminal – ''Staphylococcus aureus''
+
**[[2reu]] – SaENN C terminal – ''Staphylococcus aureus''<br />
 +
**[[4pxg]] – SaENN (mutant) <br />
*HpyI ENN
*HpyI ENN
Line 351: Line 373:
*Crossover junction ENN
*Crossover junction ENN
-
**[[2kpf]] - ENN – mouse<br />
+
**[[2kpf]] - mENN – mouse<br />
**[[2ziw]], [[2zix]], [[2ziu]] – hENN EME1 + Mus81<br />
**[[2ziw]], [[2zix]], [[2ziu]] – hENN EME1 + Mus81<br />
**[[2ziv]] – hENN EME1 (mutant) + Mus81<br />
**[[2ziv]] – hENN EME1 (mutant) + Mus81<br />
Line 375: Line 397:
**[[2bgw]] - ApENN + DNA <br />
**[[2bgw]] - ApENN + DNA <br />
**[[2bhn]] - ApENN <br />
**[[2bhn]] - ApENN <br />
 +
 +
*Mazf3 ENN
 +
 +
**[[5uct]], [[5cca]] - MtENN – ''Mycobacterium tuberculosis''<br />
 +
 +
*Muts2 ENN
 +
 +
**[[4och]], [[4od6]] - DrENN SMR domain<br />
 +
 +
*Endoms ENN
 +
 +
**[[5gkj]] – TkENN (mutant) – ''Thermococcus kodakarensis''<br />
 +
**[[5gke]], [[5gkf]], [[5gkg]], [[5gkh]], [[5gki]] – TkENN (mutant) + DNA<br />
 +
 +
*ENN G
 +
 +
**[[5gkc]], [[4qn0]] – CeENN (mutant) – ''Caenorhabdfitis elegans''<br />
 +
**[[5gkp]] – CeENN (mutant) + DNA <br />
 +
 +
*ENN V
 +
 +
**[[5aoy]] – mENN (mutant) <br />
 +
**[[4xpu]] – EcENN <br />
*'''Intron-encoded endonuclease'''
*'''Intron-encoded endonuclease'''
Line 396: Line 441:
*I-DmoI ENN
*I-DmoI ENN
-
**[[1b24]], [[2vs7]], [[2vs8]], [[4un7]], [[4un8]], [[4un9]], [[4una]], [[4unb]], [[4unc]], [[4ut0]], [[4d6n]], [[4d6o]] - DmENN + DNA – ''Desulfurococcus mobilis''<br />
+
**[[1b24]], [[2vs7]], [[2vs8]], [[4un7]], [[4un8]], [[4un9]], [[4una]], [[4unb]], [[4unc]], [[4ut0]], [[4d6n]], [[4d6o]], [[5ak9]], [[5a0w]] - DmENN + DNA – ''Desulfurococcus mobilis''<br />
 +
**[[5akf]], [[5akm]], [[5akn]] - DmENN (mutant) + DNA <br />
**[[1mow]] – DmENN/CrENN + DNA
**[[1mow]] – DmENN/CrENN + DNA
Line 417: Line 463:
**[[1dfa]], [[1ef0]] – yENN – yeast<br />
**[[1dfa]], [[1ef0]] – yENN – yeast<br />
**[[1gpp]] – yENN (mutant) <br />
**[[1gpp]] – yENN (mutant) <br />
-
**[[1lws]], [[1lwt]], [[1r7m]], [[3c0w]], [[3c0x]], [[3ool]] - yENN + DNA<br />
+
**[[1lws]], [[1lwt]], [[1r7m]], [[3c0w]], [[3c0x]], [[3ool]], [[5a0m]] - yENN + DNA<br />
**[[3oor]] - yENN (mutant) + DNA
**[[3oor]] - yENN (mutant) + DNA
*I-PkoII ENN
*I-PkoII ENN
-
**[[2cw7]], [[2cw8]] – ENN – ''Thermococcus kodakarensis''
+
**[[2cw7]], [[2cw8]] – TkENN
*I-MspI ENN
*I-MspI ENN
Line 442: Line 488:
*I-MtuI ENN
*I-MtuI ENN
-
**[[3ifj]], [[3igd]] - MtENN (mutant) – ''Mycobacterium tuberculosis''<br />
+
**[[3ifj]], [[3igd]] - MtENN (mutant) <br />
**[[2l8l]] - MtENN
**[[2l8l]] - MtENN
Line 457: Line 503:
**[[4fz2]] – MoENN – ''Candidatus micrarchaeum''<br />
**[[4fz2]] – MoENN – ''Candidatus micrarchaeum''<br />
 +
 +
*I-Cvui ENN
 +
 +
**[[5a78]], [[5a72]], [[5a74]], [[5a77]], [[5a78]] – ENN + DNA – ''Chlorella vulgaris''<br />
 +
}}
}}
== References ==
== References ==

Revision as of 10:16, 30 April 2017

E. coli EcoRV endonuclease dimer (magenta, green) complex with DNA, (PDB code 1rva)

Drag the structure with the mouse to rotate

3D structures of endonuclease

Updated on 30-April-2017

References

  1. ↑ Nishino T, Morikawa K. Structure and function of nucleases in DNA repair: shape, grip and blade of the DNA scissors. Oncogene. 2002 Dec 16;21(58):9022-32. PMID:12483517 doi:http://dx.doi.org/10.1038/sj.onc.1206135
  2. ↑ Horvath P, Barrangou R. CRISPR/Cas, the immune system of bacteria and archaea. Science. 2010 Jan 8;327(5962):167-70. doi: 10.1126/science.1179555. PMID:20056882 doi:http://dx.doi.org/10.1126/science.1179555
  3. ↑ Flick KE, Jurica MS, Monnat RJ Jr, Stoddard BL. DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI. Nature. 1998 Jul 2;394(6688):96-101. PMID:9665136 doi:10.1038/27952

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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