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Sandbox GGC3
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. <scene name='75/752266/Sheets_and_helices/1'>Chain A </scene> contains 10 anti-parallel ß-sheets with 6 α-helices which defines the central cavity entrance. The <scene name='75/752266/Sheets_and_helices/2'>glyceryl group</scene> is located at the entrance.There are three acyl chains on the ligand bound within the cavity sn1, sn2, and <scene name='75/752266/Ligand_strutuce_alone/2'>sn3</scene> they form interactions with hydrophobic residue side chains within the cavity. The <scene name='75/752266/Surface/1'>third acyl</scene> chain is exposed to the solvent and the other two (sn1 and sn2) buried inside the LprG. | + | LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. <scene name='75/752266/Sheets_and_helices/1'>Chain A </scene> contains 10 anti-parallel ß-sheets with 6 α-helices which defines the central cavity entrance. The <scene name='75/752266/Sheets_and_helices/2'>glyceryl group</scene> is located at the entrance. At the cavity entrance the hydrophilic glyceryl interacts with <scene name='75/752266/Sn3-chain/3'> Ser72 </scene>. There are three acyl chains on the ligand bound within the cavity sn1, sn2, and <scene name='75/752266/Ligand_strutuce_alone/2'>sn3</scene> they form interactions with hydrophobic residue side chains within the cavity. The <scene name='75/752266/Surface/1'>third acyl</scene> chain is exposed to the solvent and the other two (sn1 and sn2) buried inside the LprG. The sn3 chain is near two <scene name='75/752266/Phe_leu_ile/3'>hydrophobic</scene> grooves that contain Ile, Leu, Val, and Phe. These grooves could facilitate the binding of TAG with other longer acyl chains.<ref name="rasmol" /> |
Revision as of 03:04, 1 May 2017
Mycobacterial Lipoprotein
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References
- ↑ 1.0 1.1 1.2 1.3 Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351., eCollection 2016 Jan. PMID:26751071 doi:http://dx.doi.org/10.1371/journal.ppat.1005351
