Enoyl-Acyl-Carrier Protein Reductase

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Line 22: Line 22:
**[[3oic]] – BsENR III – ''Bacillus subtilis''<BR />
**[[3oic]] – BsENR III – ''Bacillus subtilis''<BR />
-
**[[2ied]] - MtENR (mutant) - ''Mycobacterium tuberculosis''<BR />
+
**[[4trm]] - MtENR - ''Mycobacterium tuberculosis''<BR />
 +
**[[2ied]] - MtENR (mutant) <BR />
**[[3oje]] – BcENR – ''Bacillus cereus''<br />
**[[3oje]] – BcENR – ''Bacillus cereus''<br />
**[[3gns]], [[3gnt]] – SaENR – ''Staphylococcus aureus''<br />
**[[3gns]], [[3gnt]] – SaENR – ''Staphylococcus aureus''<br />
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**[[4w99]] - CtENR (mutant)<br />
**[[4w99]] - CtENR (mutant)<br />
**[[1ulu]], [[2wyu]] – TtENR – ''Thermus thermophilus''<br />
**[[1ulu]], [[2wyu]] – TtENR – ''Thermus thermophilus''<br />
-
**[[3grk]] – ENR – ''Brucella melitensis''<br />
+
**[[3grk]] – BmENR – ''Brucella melitensis''<br />
**[[3k2e]] – ApENR – ''Anaplasma phagocytophilum''<br />
**[[3k2e]] – ApENR – ''Anaplasma phagocytophilum''<br />
-
**[[4eit]] – ENR – ''Bartonella henselae''<br />
+
**[[4eit]] – BhENR – ''Bartonella henselae''<br />
-
**[[3ek2]] – BpENR – ''Burkholderia pseudomallei''<br />
+
**[[3ek2]], [[5i7e]] – BpENR – ''Burkholderia pseudomallei''<br />
**[[4nk4]] – ClENR – ''Candidatus liberibacter''<br />
**[[4nk4]] – ClENR – ''Candidatus liberibacter''<br />
**[[4m86]] - NmENR – ''Neisseria meningitidis''<br />
**[[4m86]] - NmENR – ''Neisseria meningitidis''<br />
**[[4nqz]] - PaENR – ''Pseudomonas aeruginosa''<br />
**[[4nqz]] - PaENR – ''Pseudomonas aeruginosa''<br />
 +
**[[5cfz]] - EcENR – ''Escherichia coli''<br />
 +
**[[5gvj]] - ENR (mutant) – ''Thermotoga maritima''<br />
-
*Enoyl-Acyl-Carrier Protein Reductase binary complex
+
*Enoyl-Acyl-Carrier Protein Reductase binary complex with NAD
-
**[[3oew]], [[2x22]], [[2x23]], [[1eny]], [[1enz]], [[4dqu]], [[4dre]] – MtENR+NAD<BR />
+
**[[3oew]], [[2x22]], [[2x23]], [[1eny]], [[1enz]], [[4dqu]], [[4dre]], [[4trn]] – MtENR+NAD<BR />
**[[3of2]], [[4dti]] – MtENR (mutant)+NAD<BR />
**[[3of2]], [[4dti]] – MtENR (mutant)+NAD<BR />
**[[2pr2]], [[2idz]], [[2h9i]] – MtENR+INH-NAPD<br />
**[[2pr2]], [[2idz]], [[2h9i]] – MtENR+INH-NAPD<br />
Line 48: Line 51:
**[[2aqh]], [[2aqi]], [[2aqk]], [[3oey]] – MtENR (mutant)+NADH<BR />
**[[2aqh]], [[2aqi]], [[2aqk]], [[3oey]] – MtENR (mutant)+NADH<BR />
**[[2ntj]] – MtENR+PTH-NAD<BR />
**[[2ntj]] – MtENR+PTH-NAD<BR />
-
**[[2ie0]], [[2ieb]], [[2nv6]], [[1zid]] – MtENR (mutant)+INH-NAPD<br />
 
**[[2ntv]] - ENR+PTH-NAD – ''Mycobacterium leprae''<br />
**[[2ntv]] - ENR+PTH-NAD – ''Mycobacterium leprae''<br />
**[[1vrw]], [[1v35]] – PfENR+NAD<BR />
**[[1vrw]], [[1v35]] – PfENR+NAD<BR />
**[[2nq8]] – PfENR+INH-NAD<BR />
**[[2nq8]] – PfENR+INH-NAD<BR />
-
**[[2foi]] – PfENR fragment+diaryl ether inhibitor<br />
 
-
**[[2pd3]] – HpENR+TCL – ''Helicobacter pylori''<br />
 
**[[1eno]], [[1enp]] - BnENR (mutant)+NAD – ''Brassica napus''<br />
**[[1eno]], [[1enp]] - BnENR (mutant)+NAD – ''Brassica napus''<br />
**[[1guf]] – CtENR + NAD<br />
**[[1guf]] – CtENR + NAD<br />
**[[2jjy]] – FtENR + NAD – ''Francisella tularensis''<br />
**[[2jjy]] – FtENR + NAD – ''Francisella tularensis''<br />
**[[2wyv]] - TtENR + NAD<br />
**[[2wyv]] - TtENR + NAD<br />
-
**[[2yw9]] – TtENR + NADP<br />
 
-
**[[2fhs]] - EcENR+ acyl carrier protein – ''Escherichia coli''<br />
 
-
**[[2z6i]] – SpENR II + FMN – ''Streptococcus pneumoniae''<br />
 
**[[3k31]] – ApENR + NAD<br />
**[[3k31]] – ApENR + NAD<br />
**[[4nk5]] – ClENR + NAD <br />
**[[4nk5]] – ClENR + NAD <br />
 +
**[[5koi]] – BmENR + NAD <br />
 +
**[[5tf4]] – BhENR + NAD <br />
 +
**[[4zju]] – ENR + NAD – ''Acinetobacter baumannii''<br />
 +
**[[5g2o]], [[5jai]], [[5jam]], [[5jaq]] – ENR (mutant) + NAD – ''Yersinia pestis''<br />
**[[4m87]] - NmENR+NAD<br />
**[[4m87]] - NmENR+NAD<br />
 +
**[[5trt]] – BpENR + NAD<br />
 +
 +
*Other enoyl-Acyl-Carrier Protein Reductase binary complexes
 +
 +
**[[2ie0]], [[2ieb]], [[2nv6]], [[1zid]] – MtENR (mutant)+INH-NAPD<br />
 +
**[[2foi]] – PfENR fragment+diaryl ether inhibitor<br />
 +
**[[2pd3]] – HpENR+TCL – ''Helicobacter pylori''<br />
 +
**[[2yw9]] – TtENR + NADP<br />
 +
**[[2fhs]] - EcENR+ acyl carrier protein <br />
 +
**[[2z6i]] – SpENR II + FMN – ''Streptococcus pneumoniae''<br />
 +
**[[4fs3]] – SaENR + inhibitor<br />
 +
**[[4rlh]] – BpENR + inhibitor<br />
 +
**[[4w9n]] – ENR + TCL - human<br />
*Enoyl-Acyl-Carrier Protein Reductase ternary complex
*Enoyl-Acyl-Carrier Protein Reductase ternary complex
Line 77: Line 91:
**[[2nsd]] – MtENR+NAD+piperidine derivative<br />
**[[2nsd]] – MtENR+NAD+piperidine derivative<br />
**[[4u0j]], [[4tzt]], [[4tzk]], [[4trj]], [[4u0k]] - MtENR+NAD+pyrrolidine derivative<br />
**[[4u0j]], [[4tzt]], [[4tzk]], [[4trj]], [[4u0k]] - MtENR+NAD+pyrrolidine derivative<br />
-
**[[4cod]], [[4bqp]], [[4bqr]], [[4bge]], [[4bii]], [[4oxk]], [[4oxn]], [[4oxy]], [[4r9r]], [[4r9s]] - MtENR+NAD + inhibitor<br />
+
**[[4cod]], [[4bqp]], [[4bqr]], [[4bge]], [[4bii]], [[4oxk]], [[4oxn]], [[4oxy]], [[4r9r]], [[4r9s]], [[4d0r]], [[4d0s]], [[4qxm]], [[4tro]], [[4uvd]], [[4uve]], [[4uvg]], [[4uvh]], [[4uvi]], [[5g0s]], [[5g0t]], [[5g0u]], [[5g0v]], [[5g0w]], [[5jfo]], [[5mtp]], [[5mtq]], [[5mtr]], [[5ugs]], [[5ugt]], [[5ugu]] - MtENR+NAD + inhibitor<br />
-
**[[4bgi]] - MtENR (mutant) +NAD + inhibitor<br />
+
**[[4bgi]], [[5coq]], [[5cp8]], [[5cpb]], [[5cpf]] - MtENR (mutant) +NAD + inhibitor<br />
**[[1p44]] - MtENR+NAD+indole derivative<br />
**[[1p44]] - MtENR+NAD+indole derivative<br />
**[[1bvr]] - MtENR+NAD+fatty-acyl substrate<br />
**[[1bvr]] - MtENR+NAD+fatty-acyl substrate<br />
Line 90: Line 104:
**[[4cv2]], [[4cv3]] – SaENR +NAD + inhibitor<br />
**[[4cv2]], [[4cv3]] – SaENR +NAD + inhibitor<br />
**[[4cuz]], [[4cv0]], [[4cv1]], [[4d44]], [[3nz9]] – SaENR (mutant) +NADP + inhibitor<br />
**[[4cuz]], [[4cv0]], [[4cv1]], [[4d44]], [[3nz9]] – SaENR (mutant) +NADP + inhibitor<br />
-
**[[4fs3]] – SaENR +NADP + inhibitor<br />
+
**[[4nz9]] – SaENR +NADP + inhibitor<br />
**[[2qio]] - ENR+NAD+TCL – ''Bacillus anthracis''<br />
**[[2qio]] - ENR+NAD+TCL – ''Bacillus anthracis''<br />
**[[2pd4]] – HpENR+NAD+diclosan<br />
**[[2pd4]] – HpENR+NAD+diclosan<br />
Line 99: Line 113:
**[[1qsg]], [[1d8a]], [[1c14]], [[1qg6]] - EcENR+NAD+TCL<BR />
**[[1qsg]], [[1d8a]], [[1c14]], [[1qg6]] - EcENR+NAD+TCL<BR />
**[[3pjd]], [[3pje]], [[3pjf]] – EcENR (mutant) +NAD+TCL<br />
**[[3pjd]], [[3pje]], [[3pjf]] – EcENR (mutant) +NAD+TCL<br />
-
**[[4d46]], [[4jqc]], [[4jx8]] – EcENR +NAD + inhibitor<br />
+
**[[4d46]], [[4jqc]], [[4jx8]], [[5cg1]], [[5cg2]] – EcENR +NAD + inhibitor<br />
**[[3nrc]] - FtENR+NAD+TCL<br />
**[[3nrc]] - FtENR+NAD+TCL<br />
**[[3uic]], [[4j1n]], [[4j3f]], [[4j4t]] - FtENR+NAD+imidazole derivative<br />
**[[3uic]], [[4j1n]], [[4j3f]], [[4j4t]] - FtENR+NAD+imidazole derivative<br />
Line 108: Line 122:
**[[4m89]] - NmENR+NAD+TCL <br />
**[[4m89]] - NmENR+NAD+TCL <br />
**[[4iql]] – ENR + NADPH + FMN – ''Porphyromonas gingivalis''<br />
**[[4iql]] – ENR + NADPH + FMN – ''Porphyromonas gingivalis''<br />
-
**[[4bku]] - BpENR+NAD+ inhibitor<br />
+
**[[4bku]], [[5i7f]], [[5i7s]], [[5i7v]], [[5i8w]], [[5i8z]], [[5i9l]], [[5i9m]], [[5i9n]] - BpENR+NAD+ inhibitor<br />
 +
**[[5ifl]] - BpENR+NAD+TCL <br />
**[[4q9n]] - ENR+NAD+ inhibitor – ''Chlamydia trachomatis''<br />
**[[4q9n]] - ENR+NAD+ inhibitor – ''Chlamydia trachomatis''<br />
**[[4nr0]] - PaENR+NAD+TCL <br />
**[[4nr0]] - PaENR+NAD+TCL <br />
 +
**[[4was]] – CtENR + NADPH + crotonyl CoA<br />
}}
}}

Revision as of 07:28, 1 May 2017

Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code 3fne)

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3D Structures of Enoyl-Acyl-Carrier Protein Reductase

Updated on 01-May-2017

References

  1. ↑ Freundlich JS, Wang F, Vilcheze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC. Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. ChemMedChem. 2009 Jan 7. PMID:19130456 doi:10.1002/cmdc.200800261

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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