Epoxidase

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<StructureSection load='3scf' size='450' side='right' caption='Hydroxypropylphosphonic acid epoxidase complex with fosfomycin, glycerol, NO and Fe+2 ion (PDB code [[3scf]])' scene='' pspeed='8'>
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<StructureSection load='3scf' size='350' side='right' caption='Hydroxypropylphosphonic acid epoxidase complex with fosfomycin, glycerol, NO and Fe+2 ion (PDB code [[3scf]])' scene='' pspeed='8'>
== Function ==
== Function ==
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**[[5b12]] – CoHHE B (mutant) - ''Corynebacterium'' <br />
**[[5b12]] – CoHHE B (mutant) - ''Corynebacterium'' <br />
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**[[4zd9]], [[4zu3]] – CoHHE B <br />
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**[[4zd6]], [[4zu3]] – CoHHE B <br />
**[[4z9f]] – CoHHE A (mutant) <br />
**[[4z9f]] – CoHHE A (mutant) <br />
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* 1,2-phenylacetyl-CoA epoxidase or phenylacetic acid degradation protein Paac
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**[[3pwq]], [[1otk]] – EcHHE – ''Escherichia coli'' <br />
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**[[3pvr]], [[3pvt]], [[3pvy]], [[3pw1]], [[3pw8]] – EcHHE subunit A + subunit C + CoA derivative <br />
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**[[4ii4]] – EcHHE subunit A (mutant)+ subunit C + benzoyl CoA <br />
* P450 epoxidase see [[Cytochrome P450]]
* P450 epoxidase see [[Cytochrome P450]]

Revision as of 10:21, 3 May 2017

Hydroxypropylphosphonic acid epoxidase complex with fosfomycin, glycerol, NO and Fe+2 ion (PDB code 3scf)

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3D structures of epoxidase

Updated on 03-May-2017

References

  1. McLuskey K, Cameron S, Hammerschmidt F, Hunter WN. Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14221-6. Epub 2005 Sep 26. PMID:16186494
  2. Watanabe F, Yu F, Ohtaki A, Yamanaka Y, Noguchi K, Yohda M, Odaka M. Crystal structures of halohydrin hydrogen-halide-lyases from Corynebacterium sp. N-1074. Proteins. 2015 Dec;83(12):2230-9. doi: 10.1002/prot.24938. Epub 2015 Oct 16. PMID:26422370 doi:http://dx.doi.org/10.1002/prot.24938
  3. Yun D, Dey M, Higgins LJ, Yan F, Liu HW, Drennan CL. Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis. J Am Chem Soc. 2011 Jun 30. PMID:21682308 doi:10.1021/ja2025728

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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