5hbv
From Proteopedia
(Difference between revisions)
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- | '''Unreleased structure''' | ||
- | + | ==Complex structure of Fab35 and mouse nAChR alpha1== | |
- | + | <StructureSection load='5hbv' size='340' side='right' caption='[[5hbv]], [[Resolution|resolution]] 2.70Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5hbv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HBV FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
- | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hbt|5hbt]]</td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hbv OCA], [http://pdbe.org/5hbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hbv RCSB], [http://www.ebi.ac.uk/pdbsum/5hbv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hbv ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/3L21V_BUNMU 3L21V_BUNMU]] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615]<ref>PMID:10497260</ref> [[http://www.uniprot.org/uniprot/ACHA_MOUSE ACHA_MOUSE]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Bungarus multicinctus]] | ||
+ | [[Category: Rattus norvegicus]] | ||
+ | [[Category: Chen, L]] | ||
+ | [[Category: Han, G W]] | ||
+ | [[Category: Hansen, M N]] | ||
[[Category: Noridomi, K]] | [[Category: Noridomi, K]] | ||
- | [[Category: Hansen, M.N]] | ||
[[Category: Watanabe, G]] | [[Category: Watanabe, G]] | ||
- | [[Category: | + | [[Category: Complex]] |
- | [[Category: | + | [[Category: Fab35]] |
+ | [[Category: Myasthenia gravi]] | ||
+ | [[Category: Nicotinic acetylcholine receptor alpha1]] | ||
+ | [[Category: Transport protein-toxin complex]] |
Revision as of 13:07, 4 May 2017
Complex structure of Fab35 and mouse nAChR alpha1
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