5hbv

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'''Unreleased structure'''
 
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The entry 5hbv is ON HOLD
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==Complex structure of Fab35 and mouse nAChR alpha1==
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<StructureSection load='5hbv' size='340' side='right' caption='[[5hbv]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Noridomi, K., Watanabe, G., Hansen, M.N., Han, G.W., Chen, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hbv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HBV FirstGlance]. <br>
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Description: Complex structure of Fab35 and mouse nAChR alpha1
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hbt|5hbt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hbv OCA], [http://pdbe.org/5hbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hbv RCSB], [http://www.ebi.ac.uk/pdbsum/5hbv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hbv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/3L21V_BUNMU 3L21V_BUNMU]] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615]<ref>PMID:10497260</ref> [[http://www.uniprot.org/uniprot/ACHA_MOUSE ACHA_MOUSE]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bungarus multicinctus]]
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[[Category: Rattus norvegicus]]
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[[Category: Chen, L]]
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[[Category: Han, G W]]
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[[Category: Hansen, M N]]
[[Category: Noridomi, K]]
[[Category: Noridomi, K]]
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[[Category: Hansen, M.N]]
 
[[Category: Watanabe, G]]
[[Category: Watanabe, G]]
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[[Category: Han, G.W]]
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[[Category: Complex]]
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[[Category: Chen, L]]
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[[Category: Fab35]]
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[[Category: Myasthenia gravi]]
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[[Category: Nicotinic acetylcholine receptor alpha1]]
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[[Category: Transport protein-toxin complex]]

Revision as of 13:07, 4 May 2017

Complex structure of Fab35 and mouse nAChR alpha1

5hbv, resolution 2.70Å

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