5nqh

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m (Protected "5nqh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5nqh is ON HOLD
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==Structure of the human Fe65-PTB2 homodimer==
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<StructureSection load='5nqh' size='340' side='right' caption='[[5nqh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Feilen, L.P., Haubrich, K., Sinning, I., Konietzko, U., Kins, S., Simon, B., Wild, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nqh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NQH FirstGlance]. <br>
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Description: Structure of the human Fe65-PTB2 homodimer
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nqh OCA], [http://pdbe.org/5nqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nqh RCSB], [http://www.ebi.ac.uk/pdbsum/5nqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nqh ProSAT]</span></td></tr>
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[[Category: Wild, K]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/APBB1_HUMAN APBB1_HUMAN]] Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).<ref>PMID:15031292</ref> <ref>PMID:18468999</ref> <ref>PMID:18922798</ref> <ref>PMID:19234442</ref> <ref>PMID:19343227</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Feilen, L P]]
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[[Category: Haubrich, K]]
[[Category: Kins, S]]
[[Category: Kins, S]]
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[[Category: Konietzko, U]]
[[Category: Simon, B]]
[[Category: Simon, B]]
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[[Category: Konietzko, U]]
 
[[Category: Sinning, I]]
[[Category: Sinning, I]]
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[[Category: Feilen, L.P]]
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[[Category: Wild, K]]
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[[Category: Haubrich, K]]
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[[Category: Alzheimers disease]]
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[[Category: Homodimerization]]
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[[Category: Signaling protein]]

Revision as of 13:10, 4 May 2017

Structure of the human Fe65-PTB2 homodimer

5nqh, resolution 2.60Å

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