5vhx

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m (Protected "5vhx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5vhx is ON HOLD
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==GluA2-1xGSG1L bound to ZK==
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<StructureSection load='5vhx' size='340' side='right' caption='[[5vhx]], [[Resolution|resolution]] 8.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vhx]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VHX FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZK1:{[7-MORPHOLIN-4-YL-2,3-DIOXO-6-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOXALIN-1(2H)-YL]METHYL}PHOSPHONIC+ACID'>ZK1</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vhw|5vhw]], [[5vhy|5vhy]], [[5vhz|5vhz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vhx OCA], [http://pdbe.org/5vhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vhx RCSB], [http://www.ebi.ac.uk/pdbsum/5vhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vhx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Frank, J]]
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[[Category: Grassucci, R A]]
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[[Category: Sobolevsky, A I]]
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[[Category: Twomey, E C]]
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[[Category: Yelshanskaya, M V]]
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[[Category: Ion channel]]
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[[Category: Transport protein]]

Revision as of 13:13, 4 May 2017

GluA2-1xGSG1L bound to ZK

5vhx, resolution 8.30Å

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