Ets1
From Proteopedia
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| - | <StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1' | + | <StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1'> |
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== Function == | == Function == | ||
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'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> . | '''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> . | ||
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== Relevance == | == Relevance == | ||
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Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells. | Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells. | ||
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== Structural highlights == | == Structural highlights == | ||
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Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | ||
Revision as of 10:39, 9 May 2017
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3D Structures of Ets1
Updated on 09-May-2017
References
- ↑ Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci. 2007 Oct;1114:36-47. PMID:17986575 doi:http://dx.doi.org/10.1196/annals.1396.022
- ↑ Garvie CW, Pufall MA, Graves BJ, Wolberger C. Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem. 2002 Nov 22;277(47):45529-36. Epub 2002 Sep 6. PMID:12221090 doi:10.1074/jbc.M206327200
