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5tzd
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzd OCA], [http://pdbe.org/5tzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tzd RCSB], [http://www.ebi.ac.uk/pdbsum/5tzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzd ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tzd OCA], [http://pdbe.org/5tzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tzd RCSB], [http://www.ebi.ac.uk/pdbsum/5tzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tzd ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Streptomyces are ubiquitous soil bacteria that undergo a complex developmental transition coinciding with their production of antibiotics. This transition is controlled by binding of a novel tetrameric form of the second messenger, 3-5 cyclic diguanylic acid (c-di-GMP) to the master repressor, BldD. In all domains of life, nucleotide-based second messengers allow a rapid integration of external and internal signals into regulatory pathways that control cellular responses to changing conditions. c-di-GMP can assume alternative oligomeric states to effect different functions, binding to effector proteins as monomers, intercalated dimers or, uniquely in the case of BldD, as a tetramer. However, at physiological concentrations c-di-GMP is a monomer and little is known about how higher oligomeric complexes assemble on effector proteins and if intermediates in assembly pathways have regulatory significance. Here, we show that c-di-GMP binds BldD using an ordered, sequential mechanism and that BldD function necessitates the assembly of the BldD2-(c-di-GMP)4 complex. | ||
| + | |||
| + | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.,Schumacher MA, Zeng W, Findlay KC, Buttner MJ, Brennan RG, Tschowri N Nucleic Acids Res. 2017 Apr 26. doi: 10.1093/nar/gkx287. PMID:28449057<ref>PMID:28449057</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5tzd" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:24, 10 May 2017
Structure of the WT S. venezulae BldD-(CTD-c-di-GMP)2 assembly intermediate
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