5kd1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Sperm whale myoglobin H64A with nitrosoamphetamine== | |
| + | <StructureSection load='5kd1' size='340' side='right' caption='[[5kd1]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5kd1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KD1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QM:[(2R)-2-NITROSOPROPYL]BENZENE'>3QM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kd1 OCA], [http://pdbe.org/5kd1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kd1 RCSB], [http://www.ebi.ac.uk/pdbsum/5kd1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kd1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYG_PHYCD MYG_PHYCD]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | N-hydroxyamphetamine (AmphNHOH) is an oxidative metabolite of amphetamine and methamphetamine. It is known to form inhibitory complexes upon binding to heme proteins. However, its interactions with myoglobin (Mb) and hemoglobin (Hb) have not been reported. We demonstrate that the reactions of AmphNHOH with ferric Mb and Hb generate the respective heme-nitrosoamphetamine derivatives characterized by UV-vis spectroscopy. We have determined the X-ray crystal structure of the H64A Mb-nitrosoamphetamine complex to 1.73 A resolution. The structure reveals the N-binding of the nitroso-d-amphetamine isomer, with no significant H-bonding interactions between the ligand and the distal pocket amino acid residues. | ||
| - | + | Nitrosoamphetamine binding to myoglobin and hemoglobin: Crystal structure of the H64A myoglobin-nitrosoamphetamine adduct.,Wang B, Powell SM, Guan Y, Xu N, Thomas LM, Richter-Addo GB Nitric Oxide. 2017 Apr 24;67:26-29. doi: 10.1016/j.niox.2017.04.012. PMID:28450187<ref>PMID:28450187</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5kd1" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Guan, Y]] | [[Category: Guan, Y]] | ||
| + | [[Category: Richter-Addo, G B]] | ||
| + | [[Category: Thomas, L M]] | ||
| + | [[Category: Wang, B]] | ||
| + | [[Category: 2-nitroso-1-phenylpropane]] | ||
| + | [[Category: C-nitroso]] | ||
| + | [[Category: Heme]] | ||
| + | [[Category: Myoglobin]] | ||
| + | [[Category: N-hydroxyamphetamine]] | ||
| + | [[Category: Nitrosoalkane]] | ||
| + | [[Category: Nitrosoamphetamine]] | ||
| + | [[Category: Oxygen transport]] | ||
Revision as of 12:53, 10 May 2017
Sperm whale myoglobin H64A with nitrosoamphetamine
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