5jiv

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'''Unreleased structure'''
 
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The entry 5jiv is ON HOLD until Paper Publication
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==Molecular tweezers stabilize a disordered protein-protein interface==
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<StructureSection load='5jiv' size='340' side='right' caption='[[5jiv]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors: Bier, D., Ottmann, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5jiv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIV FirstGlance]. <br>
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Description: Molecular tweezers stabilize a disordered protein-protein interface
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19O:NATRIUM-(5,7+,9+,11+,16+,18+,20+,22+)-5,7,9,11,16,18,20,22-OCTAHYDRO-5,22 7,20 9,18 11,16-TETRAMETHANONONACEN-8,19-BISPHOSPHATE'>19O</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jiv OCA], [http://pdbe.org/5jiv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jiv RCSB], [http://www.ebi.ac.uk/pdbsum/5jiv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jiv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> [[http://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN]] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Bier, D]]
[[Category: Ottmann, C]]
[[Category: Ottmann, C]]
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[[Category: Bier, D]]
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[[Category: 14-3-3 protein]]
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[[Category: Ppi stabilization]]
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[[Category: Signaling protein]]
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[[Category: Supramolecular ligand]]

Revision as of 12:56, 10 May 2017

Molecular tweezers stabilize a disordered protein-protein interface

5jiv, resolution 2.45Å

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