Exotoxin
From Proteopedia
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<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'> | <StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'> | ||
| + | == Function == | ||
| - | Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref>. <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres. | + | Exotoxins (ET) are toxins which are secreted by Gram-positive and Gram-negative bacteria<ref>PMID:17675409</ref>. ETs are heat labile. They are highly toxic and fatal in μg quantities. ETs bind to specific receptors and have no enzymatic activity. |
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| + | == Relevance == | ||
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| + | Exotoxins are involved in tetanus, diphtheria and botulism. | ||
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| + | == Structural highlights == | ||
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| + | <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:07, 11 May 2017
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3D structures of exotoxin
Updated on 11-May-2017
References
- ↑ Hamon MA, Batsche E, Regnault B, Tham TN, Seveau S, Muchardt C, Cossart P. Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. Epub 2007 Aug 3. PMID:17675409 doi:http://dx.doi.org/10.1073/pnas.0702729104
- ↑ Fieldhouse RJ, Jorgensen R, Lugo MR, Merrill AR. The 1.8 angstrom cholix toxin crystal structure in complex with NAD and evidence for a new kinetic model. J Biol Chem. 2012 Apr 25. PMID:22535961 doi:10.1074/jbc.M111.337311
