Factor XIII

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-	{{STRUCTURE_1ggt| PDB=1ggt | SIZE=300| SCENE=Factor_XIII/Cv/1 |right|CAPTION=Human Factor XIII dimer, [[1ggt]] }}	+
		+	<StructureSection load='1ggt' size='450' side='right' caption='Human Factor XIII dimer (PDB entry [[1ggt]])' scene='Factor_XIII/Cv/1'>
	== Function ==		== Function ==
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	FXIII deficiency causes internal bleeding.		FXIII deficiency causes internal bleeding.
-		+	</StructureSection>
	== 3D Structures of Factor XIII ==		== 3D Structures of Factor XIII ==

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Revision as of 10:14, 11 May 2017

spinqualitylabelsall models Human Factor XIII dimer (PDB entry 1ggt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Factor XIII (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide[1]. Disease FXIII deficiency causes internal bleeding.

3D Structures of Factor XIII

Updated on 11-May-2017

1ggt – hFXIII - human
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin

References

1. ↑ Laki K, Lorand L. On the Solubility of Fibrin Clots. Science. 1948 Sep 10;108(2802):280. PMID:17842715 doi:http://dx.doi.org/10.1126/science.108.2802.280