5mrk
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrk OCA], [http://pdbe.org/5mrk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrk RCSB], [http://www.ebi.ac.uk/pdbsum/5mrk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrk OCA], [http://pdbe.org/5mrk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrk RCSB], [http://www.ebi.ac.uk/pdbsum/5mrk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Zika virus is considered a major global threat to human kind. Here, we present a crystal structure of one of its essential enzymes, the methyltransferase, with the inhibitor sinefungin. This structure, together with previously solved structures with bound substrates, will provide the information needed for rational inhibitor design. Based on the structural data we suggest the modification of the adenine moiety of sinefungin to increase selectivity and to covalently link it to a GTP analogue, to increase the affinity of the synthesized compounds. | ||
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| + | Structural basis of Zika virus methyltransferase inhibition by sinefungin.,Hercik K, Brynda J, Nencka R, Boura E Arch Virol. 2017 Mar 29. doi: 10.1007/s00705-017-3345-x. PMID:28357511<ref>PMID:28357511</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5mrk" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:09, 17 May 2017
Structural basis of Zika virus methyltransferase inhibition by sinefungin
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Categories: Boura, E | Hercik, K | Methyltransferase | Sinefungin | Transferase | Virus | Zika
