5u4y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5u4y is ON HOLD until Paper Publication
+
==IgG Fc bound to 3 helix of the B-domain from Protein A==
 +
<StructureSection load='5u4y' size='340' side='right' caption='[[5u4y]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5u4y]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4Y FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l6x|1l6x]], [[5u52|5u52]], [[5u66|5u66]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4y OCA], [http://pdbe.org/5u4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4y RCSB], [http://www.ebi.ac.uk/pdbsum/5u4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4y ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The well-studied B-domain from Staphylococcal protein A is a 59 amino acid three-helix bundle that binds the Fc portion of IgG with a dissociation constant of ~35 nM. The B-domain variant bearing a Gly to Ala mutation (=Z-domain) has been the subject of efforts to minimize a domain's size while retaining its function. We report X-ray crystallographic characterization of three steps in such a process using complexes with Fc: the full three-helix Z-domain, a 34 amino acid two-helix version called Z34C and a 13 amino acid single helix stabilized with an exo-helix tether, called LH1.
-
Authors: Ultsch, M.H., Eigenbrot, C.
+
3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix.,Ultsch M, Braisted A, Maun HR, Eigenbrot C Protein Eng Des Sel. 2017 May 5:1-7. doi: 10.1093/protein/gzx029. PMID:28475752<ref>PMID:28475752</ref>
-
Description: IgG Fc bound to 3 helix of the B-domain from Protein A
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Ultsch, M.H]]
+
<div class="pdbe-citations 5u4y" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Eigenbrot, C]]
[[Category: Eigenbrot, C]]
 +
[[Category: Ultsch, M H]]
 +
[[Category: B-domain]]
 +
[[Category: Fc]]
 +
[[Category: Helix]]
 +
[[Category: Igg1]]
 +
[[Category: Protein some]]
 +
[[Category: Transcription]]

Revision as of 15:44, 17 May 2017

IgG Fc bound to 3 helix of the B-domain from Protein A

5u4y, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5u4y"
Personal tools