2nd5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Lysine dimethylated FKBP12== | |
| - | + | <StructureSection load='2nd5' size='340' side='right' caption='[[2nd5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2nd5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ND5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ND5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nd5 OCA], [http://pdbe.org/2nd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2nd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nd5 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Peptidylprolyl isomerase]] | ||
[[Category: Fujiwara, T]] | [[Category: Fujiwara, T]] | ||
| - | [[Category: Ikegami, T]] | ||
[[Category: Furuita, K]] | [[Category: Furuita, K]] | ||
[[Category: Hattori, Y]] | [[Category: Hattori, Y]] | ||
| - | [[Category: | + | [[Category: Ikegami, T]] |
| + | [[Category: Kobayashi, N]] | ||
| + | [[Category: Kojima, C]] | ||
[[Category: Ohki, I]] | [[Category: Ohki, I]] | ||
| + | [[Category: Sebera, J]] | ||
[[Category: Sugiki, T]] | [[Category: Sugiki, T]] | ||
| - | [[Category: | + | [[Category: Sychrovsky, V]] |
| - | [[Category: | + | [[Category: Tanaka, Y]] |
| - | [[Category: | + | [[Category: Isomerase]] |
| + | [[Category: Lysine]] | ||
| + | [[Category: Methylation]] | ||
| + | [[Category: Salt bridge]] | ||
Revision as of 15:45, 17 May 2017
Lysine dimethylated FKBP12
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Categories: Peptidylprolyl isomerase | Fujiwara, T | Furuita, K | Hattori, Y | Ikegami, T | Kobayashi, N | Kojima, C | Ohki, I | Sebera, J | Sugiki, T | Sychrovsky, V | Tanaka, Y | Isomerase | Lysine | Methylation | Salt bridge
