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Galactosidase

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Line 30: Line 30:
**[[3lx9]], [[3lxa]], [[3lxb]], [[3lxc]], [[3tv8]] - hAgal A (mutant) – human<br />
**[[3lx9]], [[3lxa]], [[3lxb]], [[3lxc]], [[3tv8]] - hAgal A (mutant) – human<br />
**[[3hg2]], [[3gxn]], [[1r46]], [[1r47]], [[3s5y]], [[3s5z]] – hAgal A<br />
**[[3hg2]], [[3gxn]], [[1r46]], [[1r47]], [[3s5y]], [[3s5z]] – hAgal A<br />
-
**[[1zy9]] – TmAgal – ''Thermotoga maritima''<br />
+
**[[1zy9]], [[5m0x]] – TmAgal – ''Thermotoga maritima''<br />
**[[3h53]] - hAgal B (mutant)<br />
**[[3h53]] - hAgal B (mutant)<br />
**[[3a24]] – BtAgal – ''Bacterioides thetaiotamicron''<br />
**[[3a24]] – BtAgal – ''Bacterioides thetaiotamicron''<br />
Line 39: Line 39:
**[[2xn0]], [[2xn1]] – LaAgal – ''Lactobacillus acidophilus''<br />
**[[2xn0]], [[2xn1]] – LaAgal – ''Lactobacillus acidophilus''<br />
**[[4fnp]], [[4ojy]] – GsAgal (mutant) – ''Geobacillus stearothermophilus''<br />
**[[4fnp]], [[4ojy]] – GsAgal (mutant) – ''Geobacillus stearothermophilus''<br />
-
**[[4fnq]], [[4fnr]], [[4oif]] – GsAgal
+
**[[4fnq]], [[4fnr]], [[4oif]] – GsAgal<br />
 +
**[[4xpo]] - PsBgal – ''Pedobacter saltans'' <br />
 +
**[[4xpr]] - PsAgal (mutant)<br />
*''α-galactosidase binary complex''
*''α-galactosidase binary complex''
Line 53: Line 55:
**[[1t0o]] – HjAgal + galactose<br />
**[[1t0o]] – HjAgal + galactose<br />
**[[2xn2]] - LaAgal + galactose<br />
**[[2xn2]] - LaAgal + galactose<br />
 +
**[[4xpp]] - PsAgal + galactose<br />
 +
**[[4xpq]] - PsAgal + fucose<br />
 +
**[[4xps]] - PsAgal (mutant) + galactopyranoside derivative<br />
**[[4fns]] - GsAgal (mutant) + jirimycin derivative<br />
**[[4fns]] - GsAgal (mutant) + jirimycin derivative<br />
-
**[[4fnt]], [[4fnu]] – GsAgal + galactoside
+
**[[4fnt]], [[4fnu]] – GsAgal + galactoside<br />
 +
**[[5e1q]] - BtAgal + Gal-Lac<br />
 +
**[[5m12]], [[5m16]], [[5m1i]] - TmAgal + sugar<br />
*β-Galactosidase
*β-Galactosidase
**[[3og2]] – TrBgal – ''Trichoderma reesei''<br />
**[[3og2]] – TrBgal – ''Trichoderma reesei''<br />
-
**[[3muy]], [[3i3e]], [[3iap]], [[3iaq]], [[3dyp]], [[1px3]], [[3sep]], [[3t0a]], [[3t2o]], [[3vd3]], [[3vd5]], [[3vda]], [[4duv]] – EcBgal (mutant) – ''Escherichia coli''<br />
+
**[[3muy]], [[3i3e]], [[3iap]], [[3iaq]], [[3dym]], [[3dyp]], [[1px3]], [[3sep]], [[3t0a]], [[3t2o]], [[3vd3]], [[3vd5]], [[3vda]], [[4duv]] – EcBgal (mutant) – ''Escherichia coli''<br />
**[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal<br />
**[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal<br />
**[[3j7h]] – EcBgal – cryo EM<br />
**[[3j7h]] – EcBgal – cryo EM<br />
-
**[[3dec]], [[3d3a]], [[3bga]] – BtBgal<br />
+
**[[3dec]], [[3d3a]], [[3bga]], [[5mt2]], [[5mui]], [[5muj]] – BtBgal<br />
**[[1yq2]] - Bgal (mutant) – Arthrobacter<br />
**[[1yq2]] - Bgal (mutant) – Arthrobacter<br />
-
**[[1uwi]], [[4eam]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br />
+
**[[1uwi]], [[4eam]], [[5i3d]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br />
-
**[[1uwq]], [[4gow]] – SsBgal<br />
+
**[[1uwq]], [[1gow]] – SsBgal<br />
**[[1kwg]] – TtBgal – ''Thermus thermophilus''<br />
**[[1kwg]] – TtBgal – ''Thermus thermophilus''<br />
**[[1tg7]] – PeBgal – ''Penicillium''<br />
**[[1tg7]] – PeBgal – ''Penicillium''<br />
-
**[[3tts]] – BcBgal – ''Bacillus circulans''<br />
+
**[[3tts]], [[4mad]] – BcBgal – ''Bacillus circulans''<br />
 +
**[[4ypj]] - BcBgal (mutant) <br />
**[[4ha3]], [[4ha4]] – Bgal – ''Acidilobus saccharovorans''<br />
**[[4ha3]], [[4ha4]] – Bgal – ''Acidilobus saccharovorans''<br />
**[[3w5f]] – toBgal – tomato<br />
**[[3w5f]] – toBgal – tomato<br />
Line 77: Line 85:
**[[4uoq]] - BaBgal (mutant) – ''Bifidobacterium animalis''<br />
**[[4uoq]] - BaBgal (mutant) – ''Bifidobacterium animalis''<br />
**[[3ob8]], [[3oba]] – Bgal – ''Kluyveromyces lactis''<br />
**[[3ob8]], [[3oba]] – Bgal – ''Kluyveromyces lactis''<br />
 +
**[[5dfa]] - GsBgal (mutant) <br />
 +
**[[5dmy]] - BbBgal – ''Bifidobacterium bifidum''<br />
 +
**[[5e9a]] - Bgal - ''Rahnella''<br />
 +
**[[5euv]] - ParBgal - ''Paracoccus''<br />
 +
**[[5iaz]] - rBgal C-terminal - NMR<br />
 +
**[[5ifp]] - Bgal – ''Aspergillus niger''<br />
*''β-Galactosidase binary complex with galactose''
*''β-Galactosidase binary complex with galactose''
Line 94: Line 108:
**[[4uni]] - BaBgal + galactose <br />
**[[4uni]] - BaBgal + galactose <br />
**[[4uoz]] - BaBgal (mutant) + galactose <br />
**[[4uoz]] - BaBgal (mutant) + galactose <br />
 +
**[[4ucf]], [[4uzs]] - BbBgal + galactose <br />
 +
**[[5ldr]] - ParBgal + galactose <br />
*''β-Galactosidase other complexes''
*''β-Galactosidase other complexes''
Line 100: Line 116:
**[[3ogv]] – TrBgal + inhibitor<br />
**[[3ogv]] – TrBgal + inhibitor<br />
**[[2ceq]], [[1uwr]], [[1uws]], [[1uwt]], [[1uwu]], [[2cer]] - SsBgal + inhibitor<br />
**[[2ceq]], [[1uwr]], [[1uws]], [[1uwt]], [[1uwu]], [[2cer]] - SsBgal + inhibitor<br />
-
**[[4ean]] – SsBgal + indole<br />
+
**[[4ean]], [[5ixe]] – SsBgal + indole derivative<br />
**[[3muz]], [[3i3d]], [[3dyo]], [[1px4]], [[1jyx]], [[3t08]], [[3t0b]], [[3t2p]], [[3vd4]], [[3vd9]], [[3vdc]]- EcBgal (mutant) + IPTG<br />
**[[3muz]], [[3i3d]], [[3dyo]], [[1px4]], [[1jyx]], [[3t08]], [[3t0b]], [[3t2p]], [[3vd4]], [[3vd9]], [[3vdc]]- EcBgal (mutant) + IPTG<br />
**[[3mv0]], [[3i3b]], [[3czj]], [[4v45]], [[1jz2]], [[1jz3]], [[1jz4]], [[1jz5]], [[1jz6]] - EcBgal (mutant) + intermediate<br />
**[[3mv0]], [[3i3b]], [[3czj]], [[4v45]], [[1jz2]], [[1jz3]], [[1jz4]], [[1jz5]], [[1jz6]] - EcBgal (mutant) + intermediate<br />
Line 106: Line 122:
**[[1jyn]], [[4v44]], [[1jz8]] - EcBgal (mutant) + lactose derivative<br />
**[[1jyn]], [[4v44]], [[1jz8]] - EcBgal (mutant) + lactose derivative<br />
**[[1jyn]], [[1jyw]], [[1jyv]] - EcBgal (mutant) + substrate<br />
**[[1jyn]], [[1jyw]], [[1jyv]] - EcBgal (mutant) + substrate<br />
 +
**[[5a1a]] - EcBgal + inhibitor – Cryo-EM<br />
**[[1jz6]] - EcBgal (mutant) + inhibitor<br />
**[[1jz6]] - EcBgal (mutant) + inhibitor<br />
**[[4duw]] - EcBgal (mutant) + allolactose<br />
**[[4duw]] - EcBgal (mutant) + allolactose<br />
Line 113: Line 130:
**[[3wez]] - hBgal + NOEV<br />
**[[3wez]] - hBgal + NOEV<br />
**[[3wf0]], [[3wf1]] - hBgal + pyrimidine derivative<br />
**[[3wf0]], [[3wf1]] - hBgal + pyrimidine derivative<br />
 +
**[[3wf4]] - hBgal (mutant) + pyridine derivative<br />
**[[3wf2]] - hBgal + piperidine derivative<br />
**[[3wf2]] - hBgal + piperidine derivative<br />
**[[4cu7]] - SpBgal catalytic module + galacto-isofagomine<br />
**[[4cu7]] - SpBgal catalytic module + galacto-isofagomine<br />

Revision as of 09:48, 23 May 2017

Glycosylated beta-galactosidase complex with galactose (PDB entry 3w5g)

Drag the structure with the mouse to rotate

3D Structures of Galactosidase

Updated on 23-May-2017

References

  1. ↑ Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
  2. ↑ Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
  3. ↑ Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
  4. ↑ Morrone A, Bardelli T, Donati MA, Giorgi M, Di Rocco M, Gatti R, Parini R, Ricci R, Taddeucci G, D'Azzo A, Zammarchi E. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Hum Mutat. 2000;15(4):354-66. PMID:10737981 doi:<354::AID-HUMU8>3.0.CO;2-L 10.1002/(SICI)1098-1004(200004)15:4<354::AID-HUMU8>3.0.CO;2-L
  5. ↑ Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J Mol Biol. 2002 Sep 6;322(1):79-91. PMID:12215416


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Michal Harel, Alexander Berchansky

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