1ves
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ver|1VER]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ves FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ves OCA], [http://www.ebi.ac.uk/pdbsum/1ves PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ves RCSB]</span> | ||
}} | }} | ||
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[[Category: ig vnar]] | [[Category: ig vnar]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:23:28 2008'' |
Revision as of 21:23, 30 March 2008
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| , resolution 2.18Å | |||||||
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| Related: | 1VER
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of New Antigen Receptor variable domain from sharks
Overview
The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2. Structural features include, first, an Ig superfamily topology transitional between cell adhesion molecules, antibodies, and T cell receptors; and, second, a vestigial complementarity-determining region 2 at the "bottom" of the molecule, apparently discontinuous from the antigen-binding paratope and similar to that observed in cell adhesion molecules. Thus, we suggest that IgNARs originated as cell-surface adhesion molecules coopted to the immune repertoire and represent an evolutionary lineage independent of variable heavy chain/variable light chain type antibodies. Additionally, both 12Y-1 and 12Y-2 form unique crystallographic dimers, predominantly mediated by main-chain framework interactions, which represent a possible model for primordial cell-based interactions. Unusually, the 12Y-2 complementarity-determining region 3 also adopts an extended beta-hairpin structure, suggesting a distinct selective advantage in accessing cryptic antigenic epitopes.
About this Structure
1VES is a Single protein structure of sequence from Orectolobus maculatus. Full crystallographic information is available from OCA.
Reference
Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor., Streltsov VA, Varghese JN, Carmichael JA, Irving RA, Hudson PJ, Nuttall SD, Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12444-9. Epub 2004 Aug 10. PMID:15304650
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