5jsw
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 6-amino-2-((((3a'R,6'R,6a'R)-2,2,2',2'-tetramethyldihydro-3a'H-spiro[[1,3]dioxolane-4,4'-furo[3,4-d][1,3]dioxol]-6'-yl)methyl)amino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one== | |
| - | + | <StructureSection load='5jsw' size='340' side='right' caption='[[5jsw]], [[Resolution|resolution]] 1.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jsw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JSW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MM:6-AMINO-2-({[(3AR,4S,6R,6AR)-2,2,2,2-TETRAMETHYLDIHYDRO-3AH-SPIRO[1,3-DIOXOLANE-4,4-FURO[3,4-D][1,3]DIOXOL]-6-YL]METHYL}AMINO)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE+(NON-PREFERRED+NAME)'>6MM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p0d|1p0d]], [[4puk|4puk]], [[4kwo|4kwo]], [[4leq|4leq]], [[4lbu|4lbu]], [[5i07|5i07]], [[5jsv|5jsv]]</td></tr> |
| - | [[Category: Ehrmann, F | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jsw OCA], [http://pdbe.org/5jsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jsw RCSB], [http://www.ebi.ac.uk/pdbsum/5jsw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jsw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ehrmann, F R]] | ||
[[Category: Heine, A]] | [[Category: Heine, A]] | ||
| + | [[Category: Klebe, G]] | ||
[[Category: Nguyen, D]] | [[Category: Nguyen, D]] | ||
| - | [[Category: | + | [[Category: Carbohydrate]] |
| + | [[Category: Co-crystallization]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase inhibitor]] | ||
Revision as of 13:43, 24 May 2017
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 6-amino-2-((((3a'R,6'R,6a'R)-2,2,2',2'-tetramethyldihydro-3a'H-spiro[[1,3]dioxolane-4,4'-furo[3,4-d][1,3]dioxol]-6'-yl)methyl)amino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one
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