5nxc

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m (Protected "5nxc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5nxc is ON HOLD
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==LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736==
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<StructureSection load='5nxc' size='340' side='right' caption='[[5nxc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Mathea, S., Salah, E., Pike, A.C.W., Bushell, S., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Knapp, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5nxc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NXC FirstGlance]. <br>
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Description: LIM Domain Kinase (LIMK1) In Complex With PF-00477736
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9DB:(2~{R})-2-AZANYL-2-CYCLOHEXYL-~{N}-[2-(1-METHYLPYRAZOL-4-YL)-9-OXIDANYLIDENE-3,10,11-TRIAZATRICYCLO[6.4.1.0^{4,13}]TRIDECA-1,4,6,8(13),11-PENTAEN-6-YL]ETHANAMIDE'>9DB</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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[[Category: Mathea, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxc OCA], [http://pdbe.org/5nxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxc RCSB], [http://www.ebi.ac.uk/pdbsum/5nxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxc ProSAT]</span></td></tr>
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[[Category: Pike, A.C.W]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Disease ==
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[[Category: Von Delft, F]]
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[[http://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN]] Williams syndrome. Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
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[[Category: Bullock, A.N]]
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== Function ==
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[[http://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN]] Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.<ref>PMID:10196227</ref> <ref>PMID:10436159</ref> <ref>PMID:11832213</ref> <ref>PMID:12807904</ref> <ref>PMID:15660133</ref> <ref>PMID:16230460</ref> <ref>PMID:18028908</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Bullock, A N]]
[[Category: Bushell, S]]
[[Category: Bushell, S]]
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[[Category: Carpenter, E P]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
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[[Category: Edwards, A.M]]
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[[Category: Mathea, S]]
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[[Category: Pike, A C.W]]
[[Category: Salah, E]]
[[Category: Salah, E]]
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[[Category: Bountra, C]]
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[[Category: Kinase actin cytoskeleton inhibitor]]
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[[Category: Carpenter, E.P]]
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[[Category: Transferase]]

Revision as of 13:47, 24 May 2017

LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736

5nxc, resolution 2.25Å

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