Glucocorticoid receptor
From Proteopedia
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<StructureSection load='3g6r' size='350' side='right' caption='Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry [[3g6r]])' scene=''> | <StructureSection load='3g6r' size='350' side='right' caption='Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry [[3g6r]])' scene=''> | ||
== Function == | == Function == | ||
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**[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | **[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | ||
**[[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> | **[[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> | ||
- | **[[4hn5]], [[4hn6]] - hGCR DBD + DNA – human<br /> | + | **[[4hn5]], [[4hn6]], [[5emp]], [[5emq]], [[5emc]], [[5e69]], [[5e6a]], [[5e6b]], [[5e6c]], [[5e6d]], [[5cbx]], [[5cby]], [[5cbz]] - hGCR DBD + DNA – human<br /> |
+ | **[[5cc1]] - hGCR DBD (mutant) + DNA <br /> | ||
*Glucocorticoid receptor LBD domain | *Glucocorticoid receptor LBD domain | ||
+ | **[[4udc]], [[4udd]] - hGCR LBD (mutant) + NCOA2 peptide <br /> | ||
**[[1m2z]], [[3cld]], [[3bqd]], [[4lsj]], [[4p6w]], [[4p6x]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> | **[[1m2z]], [[3cld]], [[3bqd]], [[4lsj]], [[4p6w]], [[4p6x]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> | ||
- | **[[3e7c]], [[4csj]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist<br /> | + | **[[3e7c]], [[4csj]], [[5g3j]], [[5g5w]], [[5g3j]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist<br /> |
**[[4mdd]] - hGCR LBD (mutant) + NCOA1 peptide + non-steroidal agonist<br /> | **[[4mdd]] - hGCR LBD (mutant) + NCOA1 peptide + non-steroidal agonist<br /> | ||
**[[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> | **[[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> |
Revision as of 09:18, 25 May 2017
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3D structures of glucocorticoid receptor
Updated on 25-May-2017
References
- ↑ Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec;58(4):782-97. PMID:17132855 doi:http://dx.doi.org/10.1124/pr.58.4.9
- ↑ Finsterwald C, Alberini CM. Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. Neurobiol Learn Mem. 2014 Jul;112:17-29. doi: 10.1016/j.nlm.2013.09.017. Epub, 2013 Oct 7. PMID:24113652 doi:http://dx.doi.org/10.1016/j.nlm.2013.09.017