Gyrase
From Proteopedia
(Difference between revisions)
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*Gyrase Subunit B | *Gyrase Subunit B | ||
| - | **[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]] – GyrB+ inhibitor – ''Staphylococcus aureus''<br /> | + | **[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]] – GyrB+ inhibitor – ''Staphylococcus aureus''<br /> |
| + | **[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB ATP-binding domain + ligand<br /> | ||
| + | **[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB ATP-binding domain + antibacterial<br /> | ||
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br /> | **[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br /> | ||
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br /> | **[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br /> | ||
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**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br /> | **[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br /> | ||
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br /> | **[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br /> | ||
| - | **[[4duh]] - EcGyrB N-terminal+ inhibitor<br /> | + | **[[4duh]], [[4zvi]], [[5l3j]] - EcGyrB N-terminal+ inhibitor<br /> |
| + | **[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br /> | ||
**[[4hyp]] - EcGyrB residues 15-220 + inhibitor<br /> | **[[4hyp]] - EcGyrB residues 15-220 + inhibitor<br /> | ||
**[[1kij]] – GyrB ATPase domain+ antibiotic – ''Thermus thermophilus''<br /> | **[[1kij]] – GyrB ATPase domain+ antibiotic – ''Thermus thermophilus''<br /> | ||
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**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br /> | **[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br /> | ||
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br /> | **[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br /> | ||
| - | **[[3nuh]] – EcGyrA+EcGyrB | + | **[[3nuh]] – EcGyrA+EcGyrB<br /> |
| + | **[[5cdn]], [[5cdo]], [[5cdp]] – SaGyrA + SaGyrB + DNA<br /> | ||
| + | **[[5cdq]] - SaGyrB + GyrA + DNA + antibiotic<br /> | ||
| + | **[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br /> | ||
| + | **[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br /> | ||
| + | **[[4z2c]], [[4z2d]] - SpGyrB + GyrA + DNA – ''Streptococcus pneumoniae''<br /> | ||
| + | **[[4z2e]] - SpGyrB + GyrA + DNA + antibiotic<br /> | ||
| + | **[[5bs3]], [[5iwi]], [[5iwm]] - SaGyrB + GyrA + DNA + inhibitor<br /> | ||
| + | **[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br /> | ||
| + | **[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br /> | ||
*Reverse Gyrase | *Reverse Gyrase | ||
Revision as of 06:10, 6 June 2017
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3D Structure of Gyrase
Updated on 06-June-2017
Additional Resources
For additional information, see: Bacterial Infections
References
- ↑ Reece RJ, Maxwell A. DNA gyrase: structure and function. Crit Rev Biochem Mol Biol. 1991;26(3-4):335-75. PMID:1657531 doi:http://dx.doi.org/10.3109/10409239109114072
- ↑ Napoli A, Valenti A, Salerno V, Nadal M, Garnier F, Rossi M, Ciaramella M. Functional interaction of reverse gyrase with single-strand binding protein of the archaeon Sulfolobus. Nucleic Acids Res. 2005 Jan 26;33(2):564-76. Print 2005. PMID:15673717 doi:http://dx.doi.org/10.1093/nar/gki202
- ↑ Aubry A, Pan XS, Fisher LM, Jarlier V, Cambau E. Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity. Antimicrob Agents Chemother. 2004 Apr;48(4):1281-8. PMID:15047530
- ↑ Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen D, Lagrutta A, Bradley P, Lu J, Patel S, Rickert KW, Smith RF, Soisson S, Wei C, Fukuda H, Kishii R, Takei M, Fukuda Y. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. ACS Med Chem Lett. 2014 Mar 12;5(5):609-14. doi: 10.1021/ml500069w. eCollection, 2014 May 8. PMID:24900889 doi:http://dx.doi.org/10.1021/ml500069w
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