Histone acetyltransferase
From Proteopedia
(Difference between revisions)
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**[[2ln0]] - hHAT KAT6A<br /> | **[[2ln0]] - hHAT KAT6A<br /> | ||
**[[4ljn]] - hHAT KAT6A double PHD finger<br /> | **[[4ljn]] - hHAT KAT6A double PHD finger<br /> | ||
| + | **[[5j8c]], [[5j8f]] - hHAT KAT8 residues 177-447 (mutant)<br /> | ||
**[[2qec]] – HAT HPA2 (mutant) – ''Corynebacterium glutamicum'' | **[[2qec]] – HAT HPA2 (mutant) – ''Corynebacterium glutamicum'' | ||
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**[[4pzr]], [[4pzs]] - hHAT P300 acetyltransferase domain (mutant) + acetyl CoA<br /> | **[[4pzr]], [[4pzs]] - hHAT P300 acetyltransferase domain (mutant) + acetyl CoA<br /> | ||
**[[4pzt]] - hHAT P300 acetyltransferase domain (mutant) + acetonyl CoA<br /> | **[[4pzt]] - hHAT P300 acetyltransferase domain (mutant) + acetonyl CoA<br /> | ||
| - | + | **[[5lkt]] - hHAT P300 residues 1581-1666 + butyryl CoA<br /> | |
| + | **[[5lku]] - hHAT P300 catalytic core + CoA<br /> | ||
| + | **[[5lkx]] - hHAT P300 catalytic core (mutant) + propionyl CoA<br /> | ||
| + | **[[5lkz]] - hHAT P300 catalytic core (mutant) + crotonyl CoA<br /> | ||
| + | **[[5bt3]] - hHAT P300 bromodomain + inhibitor<br /> | ||
**[[1wug]], [[1wum]] – hHAT PCAF + small ligand | **[[1wug]], [[1wum]] – hHAT PCAF + small ligand | ||
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**[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | **[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | ||
| + | **[[5h84]] - hHAT KAT2A + propionyl CoA<br /> | ||
| + | **[[5h86]] - hHAT KAT2A + butyryl CoA<br /> | ||
| + | **[[5lvq]], [[5lvr]], [[5fdz]], [[5fe0]], [[5fe1]], [[5fe2]], [[5fe3]], [[5fe4]], [[5fe5]], [[5fe6]], [[5fe7]], [[5fe8]], [[5fe9]] - hHAT KAT2B bromodomain + inhibitor<br /> | ||
**[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | **[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | ||
| - | **[[3v43]], [[4lk9]], [[4lka]]. [[4llb]] - hHAT KAT6A + H3.1 peptide<br /> | + | **[[3v43]], [[4lk9]], [[4lka]]. [[4llb]], [[5b75]], [[5b76]], [[5b77]], [[5b78]] - hHAT KAT6A + H3.1 peptide<br /> |
| + | **[[5u2j]] - hHAT KAT6B + H3K14BU peptide<br /> | ||
| + | **[[5gk9]] - hHAT KAT7 + BRD1<br /> | ||
| + | **[[5tpx]] - HAT GCN5 + probe – ''Plasmodium falciparum''<br /> | ||
*Histone acetyltransferase ternary complexes | *Histone acetyltransferase ternary complexes | ||
| - | **[[3q33]] – yHAT RTT109 + vacuolar protein sorting-associated protein 75 + histone H3 peptide | + | **[[3q33]] – yHAT RTT109 + vacuolar protein sorting-associated protein 75 + histone H3 peptide<br /> |
| + | **[[4psx]] - yHAT B + H3 peptide + H4 peptide<br /> | ||
| + | **[[5j9q]], [[5j9t]], [[5j9u]], [[5j9w]] - yHAT Esa1 (mutant) + chromatin modification-related protein + enhancer of polycomb-like protein<br /> | ||
**[[1q2c]] - TtHAT Gcn5 + CoA + histone H4 peptide | **[[1q2c]] - TtHAT Gcn5 + CoA + histone H4 peptide | ||
Revision as of 10:35, 12 June 2017
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3D Structures of histone acetyltransferase
Updated on 12-June-2017
References
- ↑ Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem. 2001;70:81-120. PMID:11395403 doi:10.1146/annurev.biochem.70.1.81
- ↑ Dekker FJ, van den Bosch T, Martin NI. Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. Drug Discov Today. 2014 May;19(5):654-60. doi: 10.1016/j.drudis.2013.11.012. Epub, 2013 Nov 21. PMID:24269836 doi:http://dx.doi.org/10.1016/j.drudis.2013.11.012
- ↑ Van Beekum O, Kalkhoven E. Aberrant forms of histone acetyltransferases in human disease. Subcell Biochem. 2007;41:233-62. PMID:17484131
- ↑ Dutnall RN, Tafrov ST, Sternglanz R, Ramakrishnan V. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell. 1998 Aug 21;94(4):427-38. PMID:9727486
