Zika virus subgenomic flaviviral RNA
From Proteopedia
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==Crystal structure of an exonuclease resistant RNA from Zika virus== | ==Crystal structure of an exonuclease resistant RNA from Zika virus== | ||
| - | + | The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs. We found that ZIKV-infected monkey and human epithelial cells, mouse neurons, and mosquito cells produce sfRNAs. The RNA structure that is responsible for ZIKV sfRNA production forms a complex fold that is likely found in many pathogenic flaviviruses. Mutations that disrupt the structure affect exonuclease resistance in vitro and sfRNA formation during infection. The complete ZIKV xrRNA structure clarifies the mechanism of exonuclease resistance and identifies features that may modulate function in diverse flaviviruses. | |
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| + | Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.,Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS Science. 2016 Dec 2;354(6316):1148-1152. Epub 2016 Nov 10. PMID:27934765<ref>PMID:27934765</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
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==Related Structures and Topics== | ==Related Structures and Topics== | ||
| - | *[[Category: | + | *[[Category: Zika_virus| Zika virus]] |
*[[Viral Infections]] | *[[Viral Infections]] | ||
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Revision as of 16:06, 12 June 2017
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Page begun with original page seeded for PDB entry 5tpy by OCA on 04:47, January 4, 2017
Categories: Zika virus | Akiyama, B M | Beckham, J D | Costantino, D A | Kieft, J S | Laurence, H M | Massey, A R | Nix, J C | Shi, P Y | Xie, X | Yang, Y | Rna | Zika rna exonuclease resistance | Flavivirus | Topic Page
