Zika virus subgenomic flaviviral RNA
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| - | ==Crystal structure of an exonuclease resistant RNA from Zika virus== | + | ===Crystal structure of an exonuclease resistant RNA from Zika virus=== |
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| + | == Publication Abstract from PubMed == | ||
The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs. We found that ZIKV-infected monkey and human epithelial cells, mouse neurons, and mosquito cells produce sfRNAs. The RNA structure that is responsible for ZIKV sfRNA production forms a complex fold that is likely found in many pathogenic flaviviruses. Mutations that disrupt the structure affect exonuclease resistance in vitro and sfRNA formation during infection. The complete ZIKV xrRNA structure clarifies the mechanism of exonuclease resistance and identifies features that may modulate function in diverse flaviviruses. | The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs. We found that ZIKV-infected monkey and human epithelial cells, mouse neurons, and mosquito cells produce sfRNAs. The RNA structure that is responsible for ZIKV sfRNA production forms a complex fold that is likely found in many pathogenic flaviviruses. Mutations that disrupt the structure affect exonuclease resistance in vitro and sfRNA formation during infection. The complete ZIKV xrRNA structure clarifies the mechanism of exonuclease resistance and identifies features that may modulate function in diverse flaviviruses. | ||
Revision as of 16:08, 12 June 2017
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Page begun with original page seeded for PDB entry 5tpy by OCA on 04:47, January 4, 2017
Categories: Zika virus | Akiyama, B M | Beckham, J D | Costantino, D A | Kieft, J S | Laurence, H M | Massey, A R | Nix, J C | Shi, P Y | Xie, X | Yang, Y | Rna | Zika rna exonuclease resistance | Flavivirus | Topic Page
