Histone methyltransferase
From Proteopedia
(Difference between revisions)
| Line 67: | Line 67: | ||
**[[2lxe]] – AtKHMT Suvr4 SET31 - NMR<br /> | **[[2lxe]] – AtKHMT Suvr4 SET31 - NMR<br /> | ||
| - | *Histone-lysine N-methyltransferase binary complexes | + | *Histone-lysine N-methyltransferase binary complexes with DNA |
**[[2kkf]] – hKHMT Hrx CxxC domain + DNA – NMR<br /> | **[[2kkf]] – hKHMT Hrx CxxC domain + DNA – NMR<br /> | ||
**[[4nw3]] – hKHMT Mll CxxC domain + DNA <br /> | **[[4nw3]] – hKHMT Mll CxxC domain + DNA <br /> | ||
| - | **[[4z4p]] – hKHMT Mll4 SET domain + SAH <br /> | ||
**[[4pzi]] – hKHMT CxxC domain + DNA <br /> | **[[4pzi]] – hKHMT CxxC domain + DNA <br /> | ||
**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br /> | **[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain + DNA <br /> | ||
| + | **[[5ei9]], [[5eh2]], [[5egb]] - hKHMT Prdm9 zinc finger domain + DNA<br /> | ||
| + | **[[4ygi]] – AtKHMT Suvh4 + DNA<br /> | ||
| + | |||
| + | *Histone-lysine N-methyltransferase binary complexes with methyl donor | ||
| + | |||
| + | **[[4z4p]] – hKHMT Mll4 SET domain + SAH <br /> | ||
**[[3qow]] – hKHMT + SAM <br /> | **[[3qow]] – hKHMT + SAM <br /> | ||
**[[4ynm]] – hKHMT Ash1L + SAM <br /> | **[[4ynm]] – hKHMT Ash1L + SAM <br /> | ||
**[[4ypu]], [[4ype]], [[4ypa]], [[4ynp]] – hKHMT Ash1L (mutant) + SAM <br /> | **[[4ypu]], [[4ype]], [[4ypa]], [[4ynp]] – hKHMT Ash1L (mutant) + SAM <br /> | ||
| - | **[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br /> | ||
| - | **[[5mw4]], [[5mw3]], [[5mvs]], [[5juw]], [[5dtr]], [[5dtq]], [[5dtm]], [[5dt2]], [[5dsx]], [[5dry]], [[5drt]], [[4wvl]] – hKHMT DOT1L + inhibitor <br /> | ||
| - | **[[4fmu]], [[5lt8]], [[5lt7]], [[5lt6]], [[5lsz]], [[5lsy]], [[5lsx]], [[5lsu]], [[5lss]] – hKHMT SETD2 + inhibitor <br /> | ||
**[[4h12]], [[5jle]] – hKHMT SETD2 catalytic domain + SAH <br /> | **[[4h12]], [[5jle]] – hKHMT SETD2 catalytic domain + SAH <br /> | ||
**[[3smt]] – hKHMT SETD3 + SAM <br /> | **[[3smt]] – hKHMT SETD3 + SAM <br /> | ||
| + | **[[4bup]], [[3ooi]] – hKHMT SET domain + SAM <br /> | ||
| + | **[[3qox]], [[3sx0]] – hKHMT + SAH <br /> | ||
| + | **[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br /> | ||
| + | **[[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
| + | **[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
| + | **[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | ||
| + | **[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | ||
| + | **[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br /> | ||
| + | |||
| + | *Histone-lysine N-methyltransferase binary complexes with inhibitor | ||
| + | |||
| + | **[[5mw4]], [[5mw3]], [[5mvs]], [[5juw]], [[5dtr]], [[5dtq]], [[5dtm]], [[5dt2]], [[5dsx]], [[5dry]], [[5drt]], [[4wvl]] – hKHMT DOT1L + inhibitor <br /> | ||
| + | **[[4fmu]], [[5lt8]], [[5lt7]], [[5lt6]], [[5lsz]], [[5lsy]], [[5lsx]], [[5lsu]], [[5lss]] – hKHMT SETD2 + inhibitor <br /> | ||
**[[5th7]] – hKHMT SETD8 + inhibitor <br /> | **[[5th7]] – hKHMT SETD8 + inhibitor <br /> | ||
**[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br /> | **[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br /> | ||
| - | **[[4bup]], [[3ooi]] – hKHMT SET domain + SAM <br /> | ||
**[[5ke3]], [[5ke2]], [[5kco]], [[5kch]] - hKHMT SETDB1 tudor domain + inhibitor<br /> | **[[5ke3]], [[5ke2]], [[5kco]], [[5kch]] - hKHMT SETDB1 tudor domain + inhibitor<br /> | ||
| - | **[[3qox]], [[3sx0]] – hKHMT + SAH <br /> | ||
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br /> | **[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br /> | ||
| - | **[[ | + | **[[4wuy]] - hKHMT Smyd2 + inhibitor<br /> |
| + | **[[5cpr]] - hKHMT Suv420 SET domain + inhibitor<br /> | ||
| + | |||
| + | *Histone-lysine N-methyltransferase binary complexes with polypeptide | ||
| + | |||
**[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br /> | **[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br /> | ||
**[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br /> | **[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br /> | ||
| Line 94: | Line 111: | ||
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br /> | **[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br /> | ||
**[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | **[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br /> | ||
| - | **[[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
| - | **[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
| - | **[[4wuy]] - hKHMT Smyd2 + inhibitor<br /> | ||
**[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br /> | **[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br /> | ||
| - | **[[ | + | **[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> |
| - | + | ||
| - | * | + | *Histone-lysine N-methyltransferase other binary complexes |
| + | |||
**[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br /> | **[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br /> | ||
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | **[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | ||
| - | **[[ | + | **[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br /> |
| - | + | ||
| - | + | ||
| - | + | ||
*Histone-lysine N-methyltransferase ternary complex | *Histone-lysine N-methyltransferase ternary complex | ||
Revision as of 10:01, 13 June 2017
| |||||||||||
3D Structures of histone methyltransferase
Updated on 13-June-2017
References
- ↑ Trievel RC. Structure and function of histone methyltransferases. Crit Rev Eukaryot Gene Expr. 2004;14(3):147-69. PMID:15248813
- ↑ Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N. Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure. 2011 Jul 20. PMID:21782458 doi:10.1016/j.str.2011.06.011
- ↑ Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012 Apr 3;13(5):343-57. doi: 10.1038/nrg3173. PMID:22473383 doi:http://dx.doi.org/10.1038/nrg3173
- ↑ Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003 Feb 6;421(6923):652-6. Epub 2003 Jan 22. PMID:12540855 doi:10.1038/nature01378
